{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:42:15Z","timestamp":1768585335730,"version":"3.49.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Phospholipase C gamma 1 (PLC\u03b31) plays an oncogenic role in several cancers, alongside its usual physiological roles. Despite studies aimed at identifying the effect of PLC\u03b31 on tumors, the pathogenic role of PLC\u03b31 in the tumorigenesis and development of hepatocellular carcinoma (HCC) remains unknown. To investigate the function of PLC\u03b31 in HCC, we generated hepatocyte\u2010specific PLC\u03b31 conditional knockout (PLC\u03b31<jats:sup>f\/f<\/jats:sup>; Alb\u2010Cre) mice and induced HCC with diethylnitrosamine (DEN). Here, we identified that hepatocyte\u2010specific PLC\u03b31 deletion effectively prevented DEN\u2010induced HCC in mice. PLC\u03b31<jats:sup>f\/f<\/jats:sup>; Alb\u2010Cre mice showed reduced tumor burden and tumor progression, as well as a decreased incidence of HCC and less marked proliferative and inflammatory responses. We also showed that oncogenic phenotypes such as repressed apoptosis, and promoted proliferation, cell cycle progression and migration, were induced by PLC\u03b31. In terms of molecular mechanism, PLC\u03b31 regulated the activation of signal transducer and activator of transcription 3 (STAT3) signaling. Moreover, PLC\u03b31 expression is elevated in human HCC and correlates with a poor prognosis in patients with HCC. Our results suggest that PLC\u03b31 promotes the pathogenic progression of HCC, and PLC\u03b31\/STAT3 axis was identified as a potential therapeutic target pathway for HCC.<\/jats:p>","DOI":"10.1002\/hep4.2077","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T17:17:06Z","timestamp":1664126226000},"page":"3234-3246","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Loss of phospholipase C\u03b31 suppresses hepatocellular carcinogenesis through blockade of STAT3\u2010mediated cancer development"],"prefix":"10.1097","volume":"6","author":[{"given":"Eun\u2010Bi","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Biomedical Sciences,Seoul National University College of Medicine,Seoul,Republic of Korea"},{"name":"Biomedical Science Project (BK21PLUS),Seoul National University College of Medicine,Seoul,Republic of 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seul\u2010Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Biomedical Sciences,Seoul National University College of Medicine,Seoul,Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song\u2010Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Biomedical Sciences,Seoul National University College of Medicine,Seoul,Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ae Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Biomedical Sciences,Seoul National University College of Medicine,Seoul,Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Mu","family":"Shin","sequence":"additional","affiliation":[{"name":"Wide River Institute of Immunology,Seoul National University,Hongcheon,Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Nyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Translational Science,National Cancer Center,Goyang,Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-7943","authenticated-orcid":false,"given":"Stephanie","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Liver Research,Li Ka Shing Faculty of Medicine, The University of Hong Kong,Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haeryoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology,Seoul National University College of Medicine,Seoul,Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular 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