{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:27:51Z","timestamp":1781011671045,"version":"3.54.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/ http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23 HL136891"],"award-info":[{"award-number":["K23 HL136891"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Cardiovascular disease is a leading complication after both liver and kidney transplantation. Factors associated with and rates of cardiovascular events (CVEs) after simultaneous liver\u2013kidney transplant (SLKT) are unknown. This was a retrospective cohort study of adult SLKT recipients between 2002 and 2017 at six centers in six United Network for Organ Sharing regions in the US Multicenter SLKT Consortium. The primary outcome was a CVE defined as hospitalization due to acute coronary syndrome, arrhythmia, congestive heart failure, or other CV causes (stroke or peripheral vascular disease) within 1\u2009year of SLKT. Among 515 SLKT subjects (mean age \u00b1 SD, 55.4 \u00b1\u200910.6\u2009years; 35.5% women; 68.1% White), 8.7% had a CVE within 1\u2009year of SLKT. The prevalence of a CVE increased from 3.3% in 2002\u20132008 to 8.9% in 2009\u20132011 to 14.0% in 2012\u20132017 (<jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0=\u00a00.0005). SLKT recipients with a CVE were older (59.9 vs. 54.9\u2009years, <jats:italic toggle=\"yes\">p<\/jats:italic>\u2009&lt;\u20090.0001) and more likely to have coronary artery disease (CAD) (37.8% vs. 18.4%, <jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0=\u00a00.002) and atrial fibrillation (AF) (27.7% vs. 7.9%, <jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0=\u00a00.003) than those without a CVE. There was a trend toward older age by era of SLKT (<jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0=\u00a00.054). In multivariate analysis adjusted for cardiac risk factors at transplant, age (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.02, 1.11), CAD (OR, 3.62; 95% CI, 1.60, 8.18), and AF (OR, 2.36; 95% CI, 1.14, 4.89) were associated with a 1\u2010year CVE after SLKT. <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: Among SLKT recipients, we observed a 4\u2010fold increase in the prevalence of 1\u2010year CVEs over time. Increasing age, CAD, and AF were the main potential explanatory factors for this trend independent of other risk factors. These findings suggest that CV risk protocols may need to be tailored to this high\u2010risk population.<\/jats:p>","DOI":"10.1002\/hep4.2108","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T10:54:37Z","timestamp":1666781677000},"page":"e2108-e2108","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Factors associated with cardiovascular events after simultaneous liver\u2013kidney transplant from the US Multicenter Simultaneous Liver\u2013Kidney Transplant Consortium"],"prefix":"10.1097","volume":"7","author":[{"given":"Jennifer","family":"Jo","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaheng","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, University of Michigan, Michigan, Ann Arbor, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, University of Michigan, Michigan, Ann Arbor, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Magee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, University of Michigan, Michigan, Ann Arbor, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3854-3417","authenticated-orcid":false,"given":"Pranab","family":"Barman","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, University of California, California, San Diego, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Duke University, North Carolina, Durham, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Schluger","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Westchester Medical Center, New York, Westchester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Walters","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, University of California, California, Los Angeles, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Biggins","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, University of Washington, Washington, Seattle, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Filipek","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, University of Washington, Washington, Seattle, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2935-0245","authenticated-orcid":false,"given":"Giuseppe","family":"Cullaro","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, University of California, California, San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, University of California, California, San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-6380","authenticated-orcid":false,"given":"Jennifer C.","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, University of California, California, San Francisco, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel J.","family":"Perreault","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Verna","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1182-0579","authenticated-orcid":false,"given":"Pratima","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, University of Michigan, Michigan, Ann Arbor, 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