{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:27:41Z","timestamp":1788341261612,"version":"build-2803163510"},"reference-count":69,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,5,12]],"date-time":"2003-05-12T00:00:00Z","timestamp":1052697600000},"content-version":"vor","delay-in-days":131,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006527","name":"Direcci\u00f3n General de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica","doi-asserted-by":"crossref","award":["PM97-0051"],"award-info":[{"award-number":["PM97-0051"]}],"id":[{"id":"10.13039\/501100006527","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006527","name":"Direcci\u00f3n General de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica","doi-asserted-by":"crossref","award":["BFI2001-1185"],"award-info":[{"award-number":["BFI2001-1185"]}],"id":[{"id":"10.13039\/501100006527","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012818","name":"Comunidad Aut\u00f3noma de Madrid","doi-asserted-by":"crossref","award":["08.5\/0078.1\/2000"],"award-info":[{"award-number":["08.5\/0078.1\/2000"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thyroid hormone deficiency during a critical period of development profoundly affects cognitive functions such as attention, learning, and memory, but the synaptic alterations underlying these deficits remain unexplored. The present study examines the effect of congenital hypothyroidism on long\u2010term synaptic plasticity. This plasticity is believed to be essential for learning and memory and for activity\u2010dependent regulation of synapse formation in the developing brain. We found that the neonatal expression of long\u2010term potentiation (LTP), long\u2010term depression (LTD), depotentiation, and de\u2010depression in hippocampal slices from hypothyroid animals was similar to that of controls. To examine the postnatal development of these plasticities, we used slices from neonatal (2\u20133 weeks) and adult (7\u20138 weeks) rats. This work demonstrates that the ability to express all these forms of synaptic plasticity is reduced in an age\u2010dependent manner in control rats. LTP and depotentiation are also downregulated in adult hypothyroid rats, but we have found that de\u2010depression is not affected during maturation. In addition, these animals express LTD at ages at which controls fail to induce it. In contrast, input\/output experiments have shown greater levels of basal synaptic efficacy in hypothyroid adults, and this effect is probably related to the higher probability of release observed by paired\u2010pulse experiments. Nevertheless, these effects appear to be unrelated to the differences observed in long\u2010term synaptic plasticity, as no correlation was found between basal synaptic efficacy and the degree of LTD and de\u2010depression. Furthermore, the NMDA\u2010receptor antagonist amino\u2010phosphonopentanoic acid (APV) completely blocked LTD, which suggests a postsynaptic locus of this alteration. Because LTD has been associated with novelty acquisition, we suggest that the greater LTD observed in adult hypothyroid rats might be related to the hyperactivity of these animals. However, other possibilities such as a retarded maturation of synaptic plasticity must be taken into account. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.10132","type":"journal-article","created":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T16:54:55Z","timestamp":1066236895000},"page":"816-825","source":"Crossref","is-referenced-by-count":48,"title":["Age\u2010dependent alterations of long\u2010term synaptic plasticity in thyroid\u2010deficient rats"],"prefix":"10.1002","volume":"13","author":[{"given":"H.","family":"Vara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mu\u00f1oz\u2010Cuevas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Colino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,5,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(91)90077-A"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2042"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02738403"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3037696"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7569903"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.2001.12.2.121"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/8123"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.20.1.157"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00255.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00160-4"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0765-5_21"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4363"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-07-02910.1993"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/381071a0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(98)00145-2"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00421.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.34100"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03181-X"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1995.1209"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015005"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051454698"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5461.2262"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00130-6"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.209ad.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1997)7:1<95::AID-HIPO10>3.0.CO;2-D"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80633-9"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(01)00013-2"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-211-43951"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3704635"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80632-7"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/35016089"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/4540"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80852-1"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(99)00111-X"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90517-7"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5435.1870"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81067-3"},{"key":"e_1_2_1_40_1","doi-asserted-by":"crossref","first-page":"8739","DOI":"10.1073\/pnas.96.15.8739","article-title":"Novelty acquisition is associated with induction of hippocampal long\u2010term depression","volume":"96","author":"Manahan\u2010Vaughan D","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.15037"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00554-2"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1997.0136"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02100.x"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.104.2.243"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90248-C"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8394601"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/369486a0"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(81)90049-2"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12676-8"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/379826a0"},{"key":"e_1_2_1_52_1","volume-title":"The hippocampus as a cognitive map","author":"O'Keefe J","year":"1978"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(79)90042-3"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.4.462"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.450010206"},{"key":"e_1_2_1_56_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0021-9258(18)48449-9","article-title":"Thyroid hormone up\u2010regulates NGFI\u2010A gene expression in rat brain during development","volume":"267","author":"Pipa\u00f3n C","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90135-1"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-10-03827.1999"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-527560-6.50020-2"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn746"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01490-3"},{"key":"e_1_2_1_62_1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1523\/JNEUROSCI.16-02-00853.1996","article-title":"Factors regulating the reversibility of long\u2010term potentiation","volume":"16","author":"Staubli U","year":"1996","journal-title":"J Neurosci"},{"key":"e_1_2_1_63_1","doi-asserted-by":"crossref","first-page":"8712","DOI":"10.1523\/JNEUROSCI.19-19-08712.1999","article-title":"Time\u2010dependent reversal of long\u2010term potentiation in area CA1 of the freely moving rat induced by theta pulse stimulation","volume":"19","author":"Staubli U","year":"1999","journal-title":"J Neurosci"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(89)90015-0"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00541-3"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-02-01577.1995"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00723.2001"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00134-4"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5421.1805"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00585-2"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.10132","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.10132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T21:56:47Z","timestamp":1700258207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.10132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":69,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/hipo.10132"],"URL":"https:\/\/doi.org\/10.1002\/hipo.10132","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}