{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:25:11Z","timestamp":1790666711551,"version":"4.1.0"},"reference-count":87,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T00:00:00Z","timestamp":1130716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schaffer collateral excitatory synapses onto CA1 pyramidal cells are subject to significant modulation by short\u2010term plasticity. This presynaptic, history\u2010dependent modulation of neurotransmitter release causes synaptic transmission to be sensitive to the frequency of the input. As a result, temporally irregular input patterns, such as those observed in vivo, produce synaptic responses over a very wide dynamic range that reflect a balance of short\u2010term facilitation and short\u2010term depression. The neonatal period is an important developmental period in the hippocampus, when functional representations of an animal's environment are being established through exploratory behavior. The strength of excitatory synapses and their modulation by short\u2010term plasticity are critical to this process. One form of short\u2010term plasticity, paired\u2010pulse facilitation, has been shown to decrease as juvenile rats mature into young adults. However, little is known about the neonatal modulation of other forms of short\u2010term plasticity, including the responses to temporally complex stimuli. We examined developmental modulation of the short\u2010term dynamics of Schaffer collateral excitatory synapses onto CA1 pyramidal cells in acute hippocampal slices, using both constant frequency stimuli and natural stimulus patterns that were taken from in vivo recording of spike patterns of hippocampal cells. In response to constant frequency stimulation, synapses in slices from young adult rats (P28\u2013P35) showed less short\u2010term depression than did those in slices from juveniles (P12\u2013P18). However, when the natural stimulus pattern (containing a wide mix of frequencies) was used, synapses from young adults instead showed more short\u2010term depression and less short\u2010term facilitation than did juveniles. Comparing the natural stimulus pattern responses with constant frequency stimulation of a similar frequency, we found that the average responses were similar in young adults (both showed modest depression). However, in juveniles, the natural pattern produced robust facilitation while constant frequency stimulation caused a large short\u2010term depression. Our results reveal that there are developmental changes both in individual forms of short\u2010term plasticity and in the relative balance between short\u2010term facilitation and short\u2010term depression that will alter the signal transfer characteristics of these synapses. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20132","type":"journal-article","created":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T19:46:23Z","timestamp":1130787983000},"page":"66-79","source":"Crossref","is-referenced-by-count":29,"title":["Responses of excitatory hippocampal synapses to natural stimulus patterns reveal a decrease in short\u2010term facilitation and increase in short\u2010term depression during postnatal development"],"prefix":"10.1002","volume":"16","author":[{"given":"James G.T.","family":"deKay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony C.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley E.","family":"Speed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn E.","family":"Dobrunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5297.221"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511574566"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1926.sp002281"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10380"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901240303"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-04-01096.1988"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp010054"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901900107"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.81.4.485"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90005-S"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2063199"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7569903"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7863330"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80477-8"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.4161"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903250204"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2665"},{"issue":"24","key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"10664","DOI":"10.1523\/JNEUROSCI.19-24-10664.1999","article-title":"Heterogeneity of synaptic plasticity at unitary CA3\u2010CA1 and CA3\u2010CA3 connections in rat hippocampal slice cultures","volume":"19","author":"Debanne D","year":"1999","journal-title":"J Neurosci"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021204"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-05-01623.1996"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(02)00015-1"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80338-4"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80687-X"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14843"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.73.5.1821"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199709080-00023"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00344-9"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(97)00152-1"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150204"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80488-2"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.4.1782"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3182"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)01001-6"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1963.sp007269"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-17-06830.1998"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.103.1.98"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.249bu.x"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-07-02685.1992"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00142-S"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00146-9"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.4.2013"},{"key":"e_1_2_1_44_1","doi-asserted-by":"crossref","first-page":"8730","DOI":"10.1523\/JNEUROSCI.18-21-08730.1998","article-title":"Endogenous neurotrophin\u20103 regulates short\u2010term plasticity at lateral perforant path\u2010granule cell synapses","volume":"18","author":"Kokaia M","year":"1998","journal-title":"J Neurosci"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3983-04.2005"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00406.2002"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10070-9"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1162\/089976699300016494"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009840"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7770778"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/7.6.523"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10021"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-14-05508.1998"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903420311"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.38.1.201"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.045948"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(83)90083-4"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(89)90063-1"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.062133"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80301-3"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/7.6.487"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01084-3"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-23-09104.1997"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-14-05392.2000"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-10-03827.1999"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.101.1.62"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-15-05858.1997"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(94)90059-0"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1998.3837"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(96)00756-7"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(96)00699-9"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(95)80032-8"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/651"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.093948"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2779(2000)6:4<258::AID-MRDD5>3.0.CO;2-H"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-09162.2000"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.2.719"},{"key":"e_1_2_1_78_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-20-07926.1997"},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01166.2003"},{"key":"e_1_2_1_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01059-9"},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00464.2004"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-22-09708.2002"},{"key":"e_1_2_1_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)01015-6"},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80341-4"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/80614"},{"key":"e_1_2_1_86_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.12.030189.000305"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80045-2"},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.64.092501.114547"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.20132","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.20132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:36:11Z","timestamp":1696617371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.20132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,31]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/hipo.20132"],"URL":"https:\/\/doi.org\/10.1002\/hipo.20132","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,31]]}}}