{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:09:32Z","timestamp":1791050972239,"version":"4.1.0"},"reference-count":96,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The concept of \u201cstructural plasticity\u201d has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show that some recovery may occur with abstinence. The neural plasticity observed in chronic alcoholism coupled with conflicting reports on alcohol\u2010induced hippocampal neuropathology make this disease ripe for reconsideration in terms of the phenomenon of adult neurogenesis. This review describes opposing neurogenic processes that occur with alcohol intoxication and abstinence following alcohol dependence and how these opposing events relate to neurodegeneration and recovery from chronic alcoholism. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20162","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T20:46:48Z","timestamp":1137617208000},"page":"287-295","source":"Crossref","is-referenced-by-count":135,"title":["Alcohol and adult neurogenesis: Roles in neurodegeneration and recovery in chronic alcoholism"],"prefix":"10.1002","volume":"16","author":[{"given":"Kimberly","family":"Nixon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1523\/JNEUROSCI.18-02-00581.1998","article-title":"Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1\/NR2A NMDA receptors","volume":"18","author":"Aanson LC","year":"1998","journal-title":"J Neurosci"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-09-03656.2002"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00055.2003"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1990.tb01822.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.4.356"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(95)02008-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901360303"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90397-7"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06260-2"},{"key":"e_1_2_1_11_1","first-page":"349","article-title":"Effect of chronic alcoholism on the human hippocampus","volume":"5","author":"Bengochea O","year":"1990","journal-title":"Histol Histopathol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agg017"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(76)90292-6"},{"key":"e_1_2_1_14_1","first-page":"263","article-title":"The role of stress in alcohol use, alcoholism treatment, and relapse","volume":"23","author":"Brady KT","year":"1999","journal-title":"Alcohol Res Health"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790040089012"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00693-9"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00932.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1040"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.653357"},{"key":"e_1_2_1_20_1","first-page":"343","volume-title":"Pharmacological effects of ethanol on the nervous system","author":"Chen WA","year":"1996"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01641.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000204791"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1990.tb01229.x"},{"key":"e_1_2_1_24_1","first-page":"197","article-title":"Alcohol, neural stem cells, and adult neurogenesis","volume":"27","author":"Crews FT","year":"2003","journal-title":"Alcohol Res Health"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(97)00538-8"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000052581.46630.C5"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000113416.65546.01"},{"key":"e_1_2_1_28_1","article-title":"Neurogenesis in adolescent brain is potently inhibited by ethanol","author":"Crews FT","journal-title":"Neuroscience"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00030-7"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03619.x"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830190015002"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1986.tb05058.x"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)38085-3"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.3.426"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/3305"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(96)00209-1"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(91)90044-W"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/15353702-0323006-07"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00127-9"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/6365"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2004.02.004"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)04572-8"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.085779"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1997)7:1<78::AID-HIPO8>3.0.CO;2-3"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199802000-00001"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04120.x"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02240.x"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1230907100"},{"key":"e_1_2_1_49_1","first-page":"15A","article-title":"Cessation of chronic alcohol drinking: effects on depression\u2010like behavior and neurogenesis in mice","volume":"29","author":"Hillman JRS","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(93)90083-Z"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.88.355"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200208270-00004"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(02)00129-7"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081011098"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200418150-00005"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.001"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.25.5.721.14580"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004060170035"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00172-2"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-19-07768.1998"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00301-1"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300234"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(2000)10:1<122::AID-HIPO13>3.0.CO;2-V"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb00768.x"},{"key":"e_1_2_1_66_1","first-page":"18","article-title":"The role of selective serotonin reuptake inhibitors in reducing alcohol consumption","volume":"62","author":"Naranjo CA","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_67_1","volume-title":"Tenth special report to the U.S. congress on alcohol and health","author":"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","year":"2000"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199501000-00004"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01214.x"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3063-04.2004"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02573.x"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(02)00715-3"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1996.0595"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(02)00078-5"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-10-03727.1997"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10393"},{"key":"e_1_2_1_77_1","series-title":"NIAAA Research Monograph","first-page":"173","volume-title":"Alcohol\u2010induced brain damage","author":"Parsons OA","year":"1993"},{"key":"e_1_2_1_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00369-5"},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1994.tb01425.x"},{"key":"e_1_2_1_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1992.tb00702.x"},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1997.tb03798.x"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01598.x"},{"key":"e_1_2_1_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.01.091"},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.566953"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083328"},{"key":"e_1_2_1_86_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026021307833"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1988.tb02551.x"},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/35066584"},{"key":"e_1_2_1_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-2267-6"},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01478.x"},{"key":"e_1_2_1_91_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.14.2.178"},{"key":"e_1_2_1_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb02032.x"},{"key":"e_1_2_1_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.09.020"},{"key":"e_1_2_1_94_1","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","article-title":"Running enhances neurogenesis, learning, and long\u2010term potentiation in mice","volume":"96","author":"van Praag H","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_1_95_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7394532"},{"key":"e_1_2_1_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01527.x"},{"key":"e_1_2_1_97_1","first-page":"119A","article-title":"Effects of antioxidants on binge drinking neurodegeneration and neurogenesis","volume":"28","author":"Zou JY","year":"2004","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.20162","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.20162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T11:54:50Z","timestamp":1694519690000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.20162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":96,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/hipo.20162"],"URL":"https:\/\/doi.org\/10.1002\/hipo.20162","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}