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Infusion of NPY into the cerebral ventricle of LH rats showed antidepressant\u2010like effects. Infusion of NPY into the CA3 region, but not the dentate gyrus (DG), produced antidepressant\u2010like effects in the LH paradigm. Infusion of NPY did not affect locomotor activity or aversive learning ability. Coadministration of BIBO3304 (a Y1 receptor antagonist) with NPY to the CA3 region blocked the antidepressant\u2010like effects of NPY, whereas coadministration of NPY with BIIE0246 (a Y2 receptor antagonist) to the CA3 region failed to block antidepressant\u2010like effects. Furthermore, infusions of [Leu<jats:sup>31<\/jats:sup> Pro<jats:sup>34<\/jats:sup>]PYY (a Y1 and Y5 receptor agonist) alone and BIIE0246 alone into the CA3 region produced the antidepressant\u2010like effects in LH rats. These results suggest that infusion of NPY into the CA3 region of hippocampus of LH rats produces antidepressant\u2010like activity through Y1 receptors and attenuating effects through Y2 receptors. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20264","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T23:54:56Z","timestamp":1170460496000},"page":"271-280","source":"Crossref","is-referenced-by-count":59,"title":["Infusion of neuropeptide Y into CA3 region of hippocampus produces antidepressant\u2010like effect via Y1 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