{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:13:49Z","timestamp":1790943229932,"version":"4.1.0"},"reference-count":76,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T00:00:00Z","timestamp":1175212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline due to neuronal loss and neural network dysfunction. It has been postulated that progressive neuronal loss in AD is consequence of the neurotoxic properties of the amyloid\u2010\u03b2 peptide (A\u03b2). In the present study, we investigated the effect of T\u2010817MA (1\u2010{3\u2010[2\u2010(1\u2010benzothiophen\u20105\u2010yl)ethoxy] propyl}\u20103\u2010azetidinol maleate), a newly synthesized neurotrophic compound, on place learning deficits in rats with hippocampal damages. To induce granule cell loss in the dentate gyrus (DG) of the hippocampus, A\u03b2 (1\u201340) was continuously infused (300 pmol\/day) into the cerebral ventricle using a mini\u2010osmotic pump for 5 weeks. Three weeks after the A\u03b2 infusion, the rats were tested in a place learning task, which required them to alternatively visit two diametrically opposed areas in an open field to obtain intracranial self\u2010stimulation reward. The results indicated that the A\u03b2\u2010infused rats without treatment of T\u2010817MA displayed learning impairment in the task; their performance level was significantly inferior to that of the vehicle rats. Treatment of T\u2010817MA (8.4 mg\/kg\/day, p.o.) significantly improved the task performance of the A\u03b2\u2010infused rats. Furthermore, T\u2010817MA prevented granule cell loss due to A\u03b2\u2010infusion, which was correlated to task performance of the rats. However, other cognitive enhancer, an acetylcholinesterase inhibitor, had no such effects. The results demonstrated that T\u2010817MA ameliorated learning deficits induced by A\u03b2 infusion, which might be attributed to neuroprotection in the hippocampus. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20281","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T21:24:57Z","timestamp":1175289897000},"page":"443-455","source":"Crossref","is-referenced-by-count":33,"title":["Ameliorative effects of a neuroprotective agent, T\u2010817MA, on place learning deficits induced by continuous infusion of amyloid\u2010\u03b2 peptide (1\u201340) in rats"],"prefix":"10.1002","volume":"17","author":[{"given":"Phuong Thi Hong","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Son Anh","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Hai","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketoshi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Nishijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-08-02896.2000"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01865-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.11.057"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.99.6.1040"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2001.tb00376.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050955"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00096-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00262-3"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2980-05.2005"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300761"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-2230-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(92)90005-X"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1077"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.083543"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6410(01)00083-0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.43701"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6474172"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01235-4"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.04.073"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90458-8"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370305"},{"key":"e_1_2_1_23_1","first-page":"5161","article-title":"Early\u2010onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease","volume":"103","author":"Jacobsen JS","year":"2006","journal-title":"Neuroscience"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90135-V"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.2000.3986"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/325733a0"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.08.036"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90833-2"},{"key":"e_1_2_1_29_1","first-page":"597","article-title":"Task dependent representations in rat hippocampal place neurons","volume":"78","author":"Kobayashi T","year":"1997","journal-title":"J Physiol"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.04.001"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb04695.x"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00248904"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706927"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1081\/CEH-120034135"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050825"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03731-9"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02100.x"},{"key":"e_1_2_1_38_1","first-page":"24","article-title":"Memory impairment and neuronal dysfunction induced by \u03b2\u2010amyloid protein in rats","volume":"174","author":"Nabeshima T","year":"1994","journal-title":"Tohoku J Exp Pharmacol"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00576-5"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(92)90093-D"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)00258-4"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90239-9"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.73.51"},{"key":"e_1_2_1_44_1","first-page":"41","article-title":"Global ischaemia: Hippocampal pathology and spatial deficits in the water maze","volume":"62","author":"Nunn JA","year":"1994","journal-title":"Brain Res"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2000.22.2.796070"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.7.1033"},{"key":"e_1_2_1_47_1","volume-title":"The Rat Brain in the Stereotaxic Coordinates","author":"Paxinos G","year":"1986"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.8.1281"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110509"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(02)00158-4"},{"key":"e_1_2_1_51_1","first-page":"1381","article-title":"Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis","volume":"100","author":"Redwine JM","year":"2003","journal-title":"Neurosci"},{"key":"e_1_2_1_52_1","first-page":"4837","article-title":"Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model","volume":"100","author":"Reilly JF","year":"2003","journal-title":"Neuroscience"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(98)01363-4"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-21-08187.1997"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-15-05703.2001"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.2001.4054"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.3.469"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(92)90139-O"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)00262-2"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.050104"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02247-7"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03449-8"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-05-01628.2001"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.2000.4274"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00388-5"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.3.408"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(99)00045-7"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1999)9:6<668::AID-HIPO8>3.0.CO;2-9"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(00)00081-4"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00166-6"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00408.x"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702811"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01337.x"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.02.036"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(00)00206-7"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-10-02950.1986"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-07-02582.1992"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.20281","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.20281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T01:29:46Z","timestamp":1700011786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.20281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,30]]},"references-count":76,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1002\/hipo.20281"],"URL":"https:\/\/doi.org\/10.1002\/hipo.20281","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,30]]}}}