{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:13:56Z","timestamp":1791036836200,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T00:00:00Z","timestamp":1196380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rett syndrome is an autism\u2010spectrum disorder caused by loss of function mutations within the gene encoding methyl CpG\u2010binding protein 2 (MeCP2). While subtle decreases in synaptic plasticity have been detected within cortical and hippocampal neurons of\n                    <jats:italic>Mecp2<\/jats:italic>\n                    \u2010null mice, only minimal information exists regarding how the loss of MeCP2 affects network activity in the brain. To address this issue, we compared the intrinsic network activities of\n                    <jats:italic>Mecp2<\/jats:italic>\n                    \u2010null hippocampal slices derived from symptomatic mice to wild\u2010type slices. Extracellular and whole\u2010cell patch recordings revealed that although spontaneous, IPSP\u2010based rhythmic activity is present in\n                    <jats:italic>Mecp2<\/jats:italic>\n                    \u2010null slices; its frequency is significantly reduced from wild\u2010type. This reduction was not associated with alterations in the gross electrophysiological properties of hippocampal neurons, but was associated with a decreased level of spontaneous glutamate receptor\u2010mediated synaptic currents in hippocampal CA3 neurons. Paradoxically, however, repetitive sharp wave\u2010like discharges were readily induced in the\n                    <jats:italic>Mecp2<\/jats:italic>\n                    \u2010null hippocampal slices by a brief train of high\u2010frequency stimulation commonly used to establish long\u2010term potentiation at wild\u2010type slices. Taken together, our data indicate that the\n                    <jats:italic>Mecp2<\/jats:italic>\n                    \u2010null hippocampal CA3 circuit has diminished basal inhibitory rhythmic activity, which in turn renders the circuitry prone to hyperexcitability. \u00a9 2007 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/hipo.20389","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T19:16:24Z","timestamp":1196450184000},"page":"294-309","source":"Crossref","is-referenced-by-count":135,"title":["The MeCP2\u2010null mouse hippocampus displays altered basal inhibitory rhythms and is prone to hyperexcitability"],"prefix":"10.1002","volume":"18","author":[{"given":"Liang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis G. 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