{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:34:45Z","timestamp":1792251285692,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T00:00:00Z","timestamp":1209427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little work has directly examined the course of hippocampal volume in children and adults with childhood maltreatment\u2010related posttraumatic stress disorder (PTSD). Data from adults suggest that hippocampal volume deficits are associated with PTSD, whereas findings from children with PTSD generally show no hippocampal volume deficits in PTSD. Additionally, the role of the amygdala in emotional response makes it a possible region for investigation in children and adults with childhood maltreatment\u2010related PTSD. The objectives of this study were 2\u2010fold: (1) to meta\u2010analytically determine whether hippocampal and amygdala volumes in children and adults with PTSD from childhood maltreatment differ from those in healthy controls, and (2) to use cross\u2010sectional findings performed with meta\u2010analyses as a proxy for longitudinal studies to estimate the course of hippocampal and amygdala volumes in child and adult subjects with PTSD from childhood maltreatment. Using electronic databases, we identified articles containing hippocampal and amygdala data for children with PTSD and adults with PTSD from childhood maltreatment. Data were extracted and effect sizes were calculated using Comprehensive Meta\u2010Analysis Version 2.0. Reduced bilateral hippocampal volume was found in adults with childhood maltreatment\u2010related PTSD compared with healthy controls, but this deficit was not seen in children with maltreatment\u2010related PTSD, suggesting hippocampal volume deficits from childhood maltreatment may not be apparent until adulthood. Greater left than right hippocampal volume was found in the adult healthy control group but not in the PTSD group. Amygdala volume in children with maltreatment\u2010related PTSD did not differ from that in healthy controls. Hippocampal volume is normal in children with maltreatment\u2010related PTSD but not in adults with PTSD from childhood maltreatment, suggesting an initially volumetrically normal hippocampus with subsequent abnormal volumetric development occurring after trauma exposure. However, longitudinal studies are needed to support these preliminary findings. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20437","type":"journal-article","created":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T17:16:40Z","timestamp":1209489400000},"page":"729-736","source":"Crossref","is-referenced-by-count":359,"title":["Hippocampal and amygdala volumes in children and adults with childhood maltreatment\u2010related posttraumatic stress disorder: A meta\u2010analysis"],"prefix":"10.1002","volume":"18","author":[{"given":"Fu L.","family":"Woon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawson W.","family":"Hedges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,29]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"467","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300528"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.8.1248"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00009-8"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/scnp.2002.31787"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00162-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.5.924"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000942"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01218-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2028"},{"key":"e_1_2_1_12_1","first-page":"136","volume-title":"Statistical Power Analysis for the Behavioural Sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000812"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00013-7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-003-0027-z"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0006-3223(99)00045-1","article-title":"A.E. Bennett Research Award. Developmental traumatology. II. Brain development","volume":"45","author":"De Bellis MD","year":"1999","journal-title":"Biol Psychiatry"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01105-2"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01459-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2007.2088"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01413-0"},{"key":"e_1_2_1_22_1","first-page":"941","article-title":"Neurobiology of anxiety disorders and implications for treatment","volume":"73","author":"Garakani A","year":"2006","journal-title":"Mt Sinai J Med"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn958"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00229-6"},{"key":"e_1_2_1_25_1","first-page":"40","volume-title":"Statistical Methods for Meta\u2010Analysis","author":"Hedges LV","year":"1985"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340007780599078"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000712500016180X"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.03.004"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950240066012"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.05.014"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.05.021"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291705005246"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504011102"},{"key":"e_1_2_1_35_1","first-page":"157","article-title":"A fail\u2010safe N for effect size in meta\u2010analysis","volume":"8","author":"Orwin RG","year":"1983","journal-title":"J Educ Stat"},{"key":"e_1_2_1_36_1","first-page":"565","article-title":"Bilateral MR volumetry of the amygdala in chronic PTSD patients","volume":"30","author":"Pavlisa G","year":"2006","journal-title":"Coll Antropol"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOTS.0000014674.84517.46"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704105080"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.3.638"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.118.2.183"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579401003029"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1364.007"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20102"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291797005242"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.08.007"},{"key":"e_1_2_1_46_1","unstructured":"US Department of Health and Human Services.2005. Child Maltreatment 2005 (contract no. GS10F0297L order no. HSP23320050013OU). Washington DC: US Department of Health and Human Services."},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.2307\/1940021"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01359-8"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2001.00601.x"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470854200"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.09.015"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.20437","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.20437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T10:49:58Z","timestamp":1699958998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.20437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,29]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1002\/hipo.20437"],"URL":"https:\/\/doi.org\/10.1002\/hipo.20437","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,29]]}}}