{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:06:49Z","timestamp":1791500809936,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T00:00:00Z","timestamp":1209427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanism by which tooth loss accelerates spatial memory impairment is unknown. The purpose of this study was to test the hypothesis that tooth loss affects trkB\u2010mRNA levels and leads to an accelerated decrease in the hippocampal cell density in rats. A radial maze was used to evaluate the spatial memory of male Wistar rats that were categorized based on the number of extracted molar teeth. Number of hippocampal pyramidal cells and the trkB\u2010mRNA expressions in the amygdala, perirhinal cortex, thalamus, and the hippocampal CA1, CA3, and CA4 areas, were evaluated using molecular biological techniques. Seven weeks after tooth extraction, maze performance was significantly lower in each tooth loss group than in the control group, and the number of extracted teeth was inversely proportional to the induction of the trkB\u2010mRNA and the hippocampal cell density. The average weight of rats increased by controlled feeding throughout the experiment without showing a significant difference between the control and experimental groups. The results indicated that, in rats, the spatial memory\u2010linked trkB\u2010mRNA was reduced in association with the tooth loss; this supports the hypothesis and suggests that teeth have a role in the prevention of spatial memory impairment. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20440","type":"journal-article","created":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T17:16:28Z","timestamp":1209489388000},"page":"542-547","source":"Crossref","is-referenced-by-count":48,"title":["Effect of tooth loss on spatial memory and trkB\u2010mRNA levels in rats"],"prefix":"10.1002","volume":"18","author":[{"given":"Kaoruko","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,29]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(95)01613-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-09-04001.1993"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00993-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00021-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01033.2002"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7886457"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)86078-0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(96)00081-7"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1037\/0097-7403.2.2.97","article-title":"Remembrance of places passed: Spatial memory in rats","volume":"2","author":"Olton DS","year":"1976","journal-title":"J Exp Psychol Anim Behav Process"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1523\/JNEUROSCI.5654-03.2004","article-title":"Brain\u2010derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala\u2010dependent fear conditioning","volume":"24","author":"Rattiner LM","year":"2004","journal-title":"J Neurosci"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02565.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(98)00123-5"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.02.013"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(02)00063-9"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00216-3"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.91.267"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903240109"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.20440","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.20440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T09:51:54Z","timestamp":1699955514000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.20440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,29]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1002\/hipo.20440"],"URL":"https:\/\/doi.org\/10.1002\/hipo.20440","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,29]]}}}