{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:32:16Z","timestamp":1759336336355},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T00:00:00Z","timestamp":1235692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Visual rating of hippocampal atrophy is often used to differentiate between normal aging and Alzheimer's disease. We investigated whether two visual rating scales of hippocampal atrophy were related to hippocampal volumes, and if visual rating was related to global, cortical and subcortical brain atrophy in persons without dementia. Within the SMART\u2010MR study, a prospective cohort study among patients with manifest arterial disease, medial temporal lobe atrophy was qualitatively rated in 95 participants without dementia (mean age 62 \u00b1 10 years) using two visual rating scales: the medial temporal lobe (MTA) score was rated on coronal oriented images and the perihippocampal cerebrospinal fluid (HCSF) score was rated on axial oriented images. Hippocampal volume assessed by manual segmentation on a 3\u2010dimensional FFE T1\u2010weighted MR image. Automated segmentation was used to quantify volumes of brain tissue and cerebrospinal fluid. Total brain volume, gray matter volume, and ventricular volume were divided by intracranial volume to obtain brain parenchymal fraction (BPF), gray matter fraction (GMF) and ventricular fraction (VF). Using ANOVA, crude hippocampal volumes were smaller with increasing MTA and HSCF scores as were hippocampal volumes normalized for intracranial volume (<jats:italic>P<\/jats:italic> &lt; 0.05). However, hippocampal volumes normalized for total brain size were not smaller with increasing MTA or HSCF scores (<jats:italic>P<\/jats:italic> = 0.33 and <jats:italic>P<\/jats:italic> = 0.49). Also, with increasing visual rating scores, BPF was smaller and VF was larger (<jats:italic>P<\/jats:italic> &lt; 0.001), and the GMF decreased with increasing HCSF score (<jats:italic>P<\/jats:italic> = 0.008). In this nondemented population, visual rating of the medial temporal lobe reflects hippocampal atrophy as well as global and subcortical atrophy. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20575","type":"journal-article","created":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T19:53:58Z","timestamp":1235764438000},"page":"1115-1122","source":"Crossref","is-referenced-by-count":12,"title":["Visual rating of the hippocampus in non\u2010demented elders: Does it measure hippocampal atrophy or other indices of brain atrophy? 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