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This study investigated the effects of neonatal stress (MS) on the expression of synaptic plasticity markers in the hippocampus and a purported relationship to cognitive processes. Spatial learning (Morris water maze) significantly increased the expression of total levels of the neural cell adhesion molecule (NCAM), as well as its three major isoforms (NCAM\u2010120, \u2010140, and \u2010180) both in the control and MS groups. Interestingly, these increases in NCAM expression after learning were lower in MS animals when compared with control rats. MS induced a significant decrease in total levels of NCAM, and specifically, in the NCAM\u2010140 isoform expression. In the hippocampus of MS rats there was a significant decrease in brain\u2010derived neurotrophic factor and synaptophysin mRNA densities. Cell proliferation, measured as BrdU\u2010positive cells, was also decreased in the dentate gyrus of MS rats. Altogether these results suggest that MS can alter normal brain development, providing a potential mechanism by which early environmental stressors may influence vulnerability to show cognitive impairments later in life. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20586","type":"journal-article","created":{"date-parts":[[2009,3,23]],"date-time":"2009-03-23T15:49:20Z","timestamp":1237823360000},"page":"1222-1231","source":"Crossref","is-referenced-by-count":153,"title":["Effects of neonatal stress on markers of synaptic plasticity in the hippocampus: Implications for spatial 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