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The memory loss in G\u2010NonP mice might be related to altered hippocampal architecture suggested by the fact that in the rat, 7 days after water maze training, there is discernible mossy fiber (MF) growth (Holahan et al. (2006) Hippocampus 16:560\u2013570; Rekart et al. (2007) Learn Mem 14:416\u2013421). In the present report, we studied the distribution of the MF system within the hippocampus of na\u00efve, untrained, G\u2010NonP mouse. In WT mice, the MF projection was restricted to the stratum lucidum of CA3 with no detectable MF innervation in distal stratum oriens (dSO). In G\u2010NonP mice, in contrast, there was an ectopic projection terminating in the CA3 dSO. Unexpectedly, there was nearly a complete loss of immunostaining for the axonal marker Tau1 in the G\u2010NonP transgenic mice in the MF terminal fields indicating that transgenesis itself leads to off\u2010target consequences (Routtenberg (1996) Trends Neurosci 19:471\u2013472). Because transgenic mice overexpressing nonmutated, wild type GAP\u201043 do not show this ectopic growth (Rekart et al., in press) and the G\u2010NonP mice overexpress a mutated form of GAP\u201043 precluding its phosphorylation by protein kinase C (PKC), the possibility exists that permanently dephosphorylated GAP\u201043 disrupts normal axonal fasciculation which gives rise to the ectopic growth into dSO. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20635","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T19:46:38Z","timestamp":1247514398000},"page":"58-64","source":"Crossref","is-referenced-by-count":13,"title":["Ectopic growth of hippocampal mossy fibers in a mutated GAP\u201043 transgenic mouse with impaired spatial memory retention"],"prefix":"10.1002","volume":"20","author":[{"given":"Matthew R.","family":"Holahan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle 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