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However, injuries to the middle\u2010aged and aged hippocampi elicit either no or dampened neurogenesis response, which could be due to an altered plasticity of NSCs and\/or the hippocampus with age. We examined whether the plasticity of NSCs to increase neurogenesis in response to a milder injury such as partial deafferentation is preserved during aging. We quantified DG neurogenesis in the hippocampus of young, middle\u2010aged, and aged F344 rats after partial deafferentation. A partial deafferentation of the left hippocampus without any apparent cell loss was induced via administration of Kainic acid (0.5 \u03bcg in 1.0 \u03bcl) into the right lateral ventricle of the brain. In this model, degeneration of CA3 pyramidal neurons and dentate hilar neurons in the right hippocampus results in loss of commissural axons which leads to partial deafferentation of the dendrites of dentate granule cells and CA1\u2010CA3 pyramidal neurons in the left hippocampus. Quantification of newly born cells that are added to the dentate granule cell layer at postdeafferentation days 4\u201315 using 5\u2032\u2010bromodeoxyuridine (BrdU) labeling revealed greatly increased addition of newly born cells (\u223cthree fold increase) in the deafferented young and middle\u2010aged hippocampi but not in the deafferented aged hippocampus. Measurement of newly born neurons using doublecortin (DCX) immunostaining also revealed similar findings. Analyses using BrdU\u2010DCX dual immunofluorescence demonstrated no changes in neuronal fate\u2010choice decision of newly born cells after deafferentation, in comparison to the age\u2010matched naive hippocampus in all age groups. Thus, the plasticity of hippocampal NSCs to increase DG neurogenesis in response to a milder injury such as partial hippocampal deafferentation is preserved until middle age but lost at old age. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20776","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T14:16:54Z","timestamp":1269353814000},"page":"631-646","source":"Crossref","is-referenced-by-count":15,"title":["Deafferentation enhances neurogenesis in the young and middle aged hippocampus but not in the aged hippocampus"],"prefix":"10.1002","volume":"21","author":[{"given":"Ashok K.","family":"Shetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharathi","family":"Hattiangady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muddanna 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