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This study examined the effect of chronic psychosocial stress in an at\u2010risk (treatment with a subpathogenic dose of A\u03b2; \u201csubA\u03b2\u201d) rat model of AD on long\u2010term memory by three techniques: memory tests in the radial arm water maze, electrophysiological recordings of synaptic plasticity in anesthetized rats, and immunoblot analysis of learning\u2010 and long\u2010term memory\u2010related signaling molecules. Chronic psychosocial stress was induced using a rat intruder model. The subA\u03b2 rat model of AD was induced by continuous infusion of 160 pmol\/day A\u03b2<jats:sub>1\u201342<\/jats:sub> via a 14\u2010day i.c.v. osmotic pump. All tests showed that subA\u03b2 rats were not different from control rats. Result from behavioral tests and electrophysiological recordings showed that infusion of subA\u03b2 in chronically stressed rats (stress\/subA\u03b2 group) caused significant impairment of cognitive functions and late\u2010phase long\u2010term potentiation (L\u2010LTP). Molecular analysis of various signaling molecules after expression of L\u2010LTP, revealed an increase in the levels of p\u2010CREB in control, stress, and subA\u03b2 rats, but not in the stress\/subA\u03b2 rats. These findings suggest that the chronic stress\u2010induced molecular alteration may accelerate the impairment of cognition and synaptic plasticity in individuals \u201cat\u2010risk\u201d for AD. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20790","type":"journal-article","created":{"date-parts":[[2010,4,13]],"date-time":"2010-04-13T14:31:19Z","timestamp":1271169079000},"page":"724-732","source":"Crossref","is-referenced-by-count":26,"title":["Chronic psychosocial stress accelerates impairment of long\u2010term memory and late\u2010phase long\u2010term potentiation in an at\u2010risk model of Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Trinh T.","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Srivareerat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim 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