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We compared effects of lesions in ReRh and other parts of the midline\u2010intralaminar complex on tasks affected by lesions in terminal fields innervated by these nuclei, including: visuospatial reaction time (VSRT), a measure of sensory guided responding; serial VSRT, a measure of action sequence learning; and win\/shift radial arm maze (RAM) measures of spatial memory. ReRh lesions affected RAM, but not VSRT or serial VSRT performance. The effects of caudal intralaminar lesions were doubly dissociated from ReRh lesions, affecting VSRT, but not RAM or serial VSRT performance. Rostral intralaminar lesions did not produce significant impairments, other than a subgroup with larger lesions that were impaired performing a delayed RAM task. Combined lesions damaging all three sites produced RAM deficits comparable to ReRh lesions and VSRT deficits comparable to caudal intralaminar lesions. Thus there was no indication that deficits produced by lesions in one site were exacerbated significantly by the cumulative effect of damage in other parts of the midline\u2010intralaminar complex. The effects of ReRh lesions provide evidence that these nuclei affect memory functions of hippocampus and medial prefrontal cortex. The double dissociation observed between the effects of ReRh and caudal intralaminar nuclei provides evidence that different nuclei within the midline\u2010intralaminar complex affect distinct aspects of cognition consistent with the effects of lesions in the terminal fields they innervate. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20797","type":"journal-article","created":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T20:03:57Z","timestamp":1277237037000},"page":"815-826","source":"Crossref","is-referenced-by-count":86,"title":["Lesions of reuniens and rhomboid thalamic nuclei impair radial maze win\u2010shift performance"],"prefix":"10.1002","volume":"21","author":[{"given":"Jacqueline R.","family":"Hembrook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert 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