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Although nicotine treatment was reported to attenuate the impairment of learning and memory and LTP associated with several mental disorders, the effect of nicotine on SD\u2010induced learning and memory impairment has not been studied. Modified multiple platform paradigm was used to induce SD for 24 or 48 h during which rats were injected with saline or nicotine (1 mg kg<jats:sup>\u22121<\/jats:sup> s.c.) twice a day. In the radial arm water maze (RAWM) task, 24\u2010 or 48\u2010h SD significantly impaired learning and short\u2010term memory. In addition, extracellular recordings from CA1 and dentate gyrus (DG) regions of the hippocampus in urethane anesthetized rats showed a significant impairment of LTP after 24\u2010 and 48\u2010h SD. Treatment of normal rats with nicotine for 24 or 48 h did not enhance spatial learning and memory or affect magnitude of LTP in the CA1 and DG regions. However, concurrent, acute treatment of rats with nicotine significantly attenuated SD\u2010induced impairment of learning and STM and prevented SD\u2010induced impairment of LTP in the CA1 and DG regions. These results show that acute nicotine treatment prevented the deleterious effect of sleep loss on cognitive abilities and synaptic plasticity. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20806","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T01:20:15Z","timestamp":1275441615000},"page":"899-909","source":"Crossref","is-referenced-by-count":78,"title":["Acute nicotine treatment prevents rem sleep deprivation\u2010induced learning and memory impairment in 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