{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:12:35Z","timestamp":1791328355809,"version":"4.3.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T00:00:00Z","timestamp":1277251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The neural representation of directional heading is encoded by a population of cells located in a circuit that includes the postsubiculum (PoS), anterodorsal thalamus (ADN), and lateral mammillary nuclei (LMN). Throughout this circuit, many cells rely on both movement\u2010 and landmark\u2010related information to discharge as a function of the animal's directional heading. The PoS projects to both the ADN and LMN, and these connections may convey critical spatial information about landmarks, because lesions of the PoS disrupt landmark control in head direction (HD) cells and hippocampal place cells [Goodridge and Taube (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib14\">1997<\/jats:ext-link>\n                    ) J Neurosci 17:9315\u20139330; Calton et al. (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib6\">2003<\/jats:ext-link>\n                    ) J Neurosci 23:9719\u20139731]. The PoS \u2192 ADN projection originates in the deep layers of PoS, but no studies have determined whether the PoS \u2192 LMN projection originates from the same cells that project to ADN. To address this issue, two distinct cholera toxin\u2010subunit B (CTB) fluorophore conjugates (Alexa Fluor 488 and Alexa Fluor 594) were injected into the LMN and ADN of the same rats, and PoS sections were examined for cell bodies containing either or both CTB conjugates. Results indicated that the PoS \u2192 LMN projection originates exclusively from a thin layer of cells located superficial to the layer(s) of PoS \u2192 ADN projection cells, with no overlap. To verify the laminar distribution and morphological characteristics of PoS \u2192 LMN and PoS \u2192 ADN cells, biotinylated dextran amine was injected into LMN or ADN of different rats, and tissue sections were counterstained with thionin. Results indicated that the PoS \u2192 LMN projection arises from large pyramidal cells in layer IV, whereas the PoS \u2192 ADN projection arises from a heterogeneous cell population in layers V\/VI. This study provides the first evidence that the PoS \u2192 ADN and PoS \u2192 LMN projections arise from distinct, nonoverlapping cell layers in PoS. Functionally, the PoS may provide landmark information to HD cells in LMN. \u00a9 2010 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/hipo.20820","type":"journal-article","created":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T11:03:23Z","timestamp":1277291003000},"page":"1062-1073","source":"Crossref","is-referenced-by-count":48,"title":["Projections to the anterodorsal thalamus and lateral mammillary nuclei arise from different cell populations within the postsubiculum: Implications for the control of head direction cells"],"prefix":"10.1002","volume":"21","author":[{"given":"Ryan M.","family":"Yoder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Taube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902860303"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0268-07.2007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.03.101"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901050305"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80657-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-30-09719.2003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.122.4.827"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.115.1.3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1523\/JNEUROSCI.3380-09.2010","article-title":"2010. 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