{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T16:54:53Z","timestamp":1763830493435},"reference-count":71,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T00:00:00Z","timestamp":1337212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We hypothesize that selective lesion of the septohippocampal GABAergic neurons suppresses the altered behaviors induced by an <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>D<\/jats:sc>\u2010aspartate (NMDA) receptor antagonist, ketamine or MK\u2010801. In addition, we hypothesize that septohippocampal GABAergic neurons generate an atropine\u2010resistant theta rhythm that coexists with an atropine\u2010sensitive theta rhythm in the hippocampus. Infusion of orexin\u2010saporin (ore\u2010SAP) into the medial septal area decreased parvalbumin\u2010immunoreactive (GABAergic) neurons by \u223c80%, without significantly affecting choline\u2010acetyltransferase\u2010immunoreactive (cholinergic) neurons. The theta rhythm during walking, or the immobility\u2010associated theta induced by pilocarpine, was not different between ore\u2010SAP and sham\u2010lesion rats. Walking theta was, however, more disrupted by atropine sulfate in ore\u2010SAP than in sham\u2010lesion rats. MK\u2010801 (0.5 mg\/kg i.p.) induced hyperlocomotion associated with an increase in frequency, but not power, of the hippocampal theta in both ore\u2010SAP and sham\u2010lesion rats. However, MK\u2010801 induced an increase in 71\u2013100 Hz gamma waves in sham\u2010lesion but not ore\u2010SAP lesion rats. In sham\u2010lesion rats, MK\u2010801 induced an increase in locomotion and an impairment of prepulse inhibition (PPI), and ketamine (3 mg\/kg s.c.) induced a loss of gating of hippocampal auditory evoked potentials. MK\u2010801\u2010induced behavioral hyperlocomotion and PPI impairment, and ketamine\u2010induced auditory gating deficit were reduced in ore\u2010SAP rats as compared to sham\u2010lesion rats. During baseline without drugs, locomotion and auditory gating were not different between ore\u2010SAP and sham\u2010lesion rats, and PPI was slightly but significantly increased in ore\u2010SAP as compared with sham lesion rats. It is concluded that septohippocampal GABAergic neurons are important for the expression of hyperactive and psychotic symptoms an enhanced hippocampal gamma activity induced by ketamine and MK\u2010801, and for generating an atropine\u2010resistant theta. Selective suppression of septohippocampal GABAergic activity is suggested to be an effective treatment of some symptoms of schizophrenia. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22039","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T18:10:40Z","timestamp":1337278240000},"page":"2208-2218","source":"Crossref","is-referenced-by-count":22,"title":["Septohippocampal GABAergic neurons mediate the altered behaviors induced by <i>n<\/i>\u2010methyl\u2010<scp>D<\/scp>\u2010aspartate receptor antagonists"],"prefix":"10.1002","volume":"22","author":[{"given":"Jingyi","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siew Kian","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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