{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:12:13Z","timestamp":1791000733135,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T00:00:00Z","timestamp":1342742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The standardized extract of the St. John's wort plant (<jats:italic><jats:styled-content>Hypericum perforatum<\/jats:styled-content><\/jats:italic>) is commonly used to treat mild to moderate depression. Its active constituent is hyperforin, a phloroglucinol derivative that reduces the reuptake of serotonin and norepinephrine by increasing intracellular Na<jats:sup>+<\/jats:sup>concentration through the activation of nonselective cationic TRPC6 channels. TRPC6 channels are also Ca<jats:sup>2+<\/jats:sup>\u2010permeable, resulting in intracellular Ca<jats:sup>2+<\/jats:sup>elevations. Indeed, hyperforin activates TRPC6\u2010mediated currents and Ca<jats:sup>2+<\/jats:sup>transients in rat PC12 cells, which induce their differentiation, mimicking the neurotrophic effect of nerve growth factor. Here, we show that hyperforin modulates dendritic spine morphology in CA1 and CA3 pyramidal neurons of hippocampal slice cultures through the activation of TRPC6 channels. Hyperforin also evoked intracellular Ca<jats:sup>2+<\/jats:sup>transients and depolarizing inward currents sensitive to the TRPC channel blocker La<jats:sup>3+<\/jats:sup>, thus resembling the actions of the neurotrophin brain\u2010derived neurotrophic factor (BDNF) in hippocampal pyramidal neurons. These results suggest that the antidepressant actions of St. John's wort are mediated by a mechanism similar to that engaged by BDNF. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22052","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T22:42:02Z","timestamp":1342824122000},"page":"40-52","source":"Crossref","is-referenced-by-count":66,"title":["Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca<sup>2+<\/sup>\u2010permeable TRPC6 channels"],"prefix":"10.1002","volume":"23","author":[{"given":"Kristina","family":"Leuner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle 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