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Our aims were to assess in vivo volumes of different hippocampal subfields in patients with PD with and without visual hallucinations using MRI and test their association with verbal learning and long\u2010term recall. A total of 18 nondemented PD patients, 18 nondemented PD patients with visual hallucinations and 18 neurologically unimpaired elderly controls matched by age and gender were enrolled in this study. We assessed the volumes of seven hippocampal subfields on MRI, including the cornu armonis (CA) sectors, subiculum, presubiculum, and the dentate gyrus (DG) using a novel technique that enables automated volumetry. The CA2\u20103 and CA4\u2010DG subfields were significantly smaller in both groups of patients, while the subiculum was only reduced in PD patients with visual hallucinations, compared to controls. Significant correlations were found between learning performance and CA2\u20103 as well as CA4\u2010DG volumes in the whole patient sample. These data show there is regional atrophy of specific hippocampal subfields in PD, which is more severe and further extends to the subiculum in patients with visual hallucinations. Our findings indicate that learning deficits are associated with volume loss in subfields that act as input regions in the hippocampal circuit, suggesting that degeneration in these regions could be responsible for cognitive dysfunction in PD. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22131","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T09:05:29Z","timestamp":1365066329000},"page":"720-728","source":"Crossref","is-referenced-by-count":70,"title":["Regional vulnerability of hippocampal subfields and memory deficits in Parkinson's disease"],"prefix":"10.1002","volume":"23","author":[{"given":"Joana B.","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Clinical Psychobiology University of Barcelona Barcelona Spain"},{"name":"Institute of Biomedical Research August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Junqu\u00e9","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Clinical Psychobiology University of Barcelona Barcelona Spain"},{"name":"Institute of Biomedical Research August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bartr\u00e9s\u2010Faz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Clinical Psychobiology University of Barcelona Barcelona Spain"},{"name":"Institute of Biomedical Research August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Ram\u00edrez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Department of 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