{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:36:10Z","timestamp":1789983370216,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T00:00:00Z","timestamp":1372982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>There is great interest in the cognitive consequences of hippocampal volume loss in developmental amnesia (DA). In many DA cases, volume loss occurs before the hippocampus is fully developed, and yet little is known about the locus, extent, and distribution of damage in these cases. We used high\u2010resolution MRI to manually segment the medial temporal lobe (MTL) subregions in H.C., an adult with DA, and a group of sex\u2010, age\u2010 and education\u2010matched control participants (<jats:italic>n<\/jats:italic> = 10). The hippocampus was defined and divided into anterior (head) and posterior (body and tail) segments. Within the body of the hippocampus, the subregions (CA<jats:sub>1<\/jats:sub>, DG\/CA<jats:sub>2\/3<\/jats:sub>, and subiculum) were defined. Finally, the entorhinal (ERC), perirhinal (PRC), and parahippocampal (PHC) cortices were segmented. Anterior hippocampus was reduced bilaterally and posterior hippocampus was significantly reduced on the right. In the body of the hippocampus, all three subregions were reduced in the left hemisphere, whereas CA<jats:sub>1<\/jats:sub> and subiculum were reduced in the right hemisphere. No group differences were observed in the PRC and ERC, whereas left PHC volume was marginally increased in H.C. compared to controls. These results can be used to inform patterns of spared and impaired cognitive abilities in DA and perhaps in amnesia more generally. \u00a9 The Authors. Hippocampus Published by Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22153","type":"journal-article","created":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T08:28:40Z","timestamp":1370680120000},"page":"855-860","source":"Crossref","is-referenced-by-count":72,"title":["Volumetric analysis of medial temporal lobe subregions in developmental amnesia using high\u2010resolution magnetic resonance imaging"],"prefix":"10.1002","volume":"23","author":[{"given":"Rosanna K.","family":"Olsen","sequence":"first","affiliation":[{"name":"Rotman Research Institute at Baycrest Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela J.","family":"Palombo","sequence":"additional","affiliation":[{"name":"Rotman Research Institute at Baycrest Toronto Ontario Canada"},{"name":"Department of Psychology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Rabin","sequence":"additional","affiliation":[{"name":"Department of Psychology York University Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Levine","sequence":"additional","affiliation":[{"name":"Rotman Research Institute at Baycrest Toronto Ontario Canada"},{"name":"Department of Psychology University of Toronto Toronto Ontario Canada"},{"name":"Department of Medicine (Neurology)  University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Rotman Research Institute at Baycrest Toronto Ontario Canada"},{"name":"Department of Psychology University of Toronto Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Shayna","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Rotman Research Institute at Baycrest Toronto Ontario Canada"},{"name":"Department of Psychology York University Toronto Ontario Canada"},{"name":"Neuroscience Graduate Diploma Program York University Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,5]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1162\/0898929053124901"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1162\/08989290151137403"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1438-y"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00290"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.12.022"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460030304"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02643290701290146"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/1932409"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/b138576"},{"key":"e_1_2_2_11_1","first-page":"637","article-title":"Methods for normalization of hippocampal volumes measured with MR","volume":"16","author":"Free SL","year":"1995","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1657"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.09.015"},{"key":"e_1_2_2_14_1","first-page":"659","article-title":"MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices","volume":"19","author":"Insausti R","year":"1998","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22549"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.63.3.385"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.10.027"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.06.011"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.03.007"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2245-09.2009"},{"key":"e_1_2_2_21_1","article-title":"Long\u2010axis specialization of the human hippocampus","author":"Poppenk J","journal-title":"Trends Cogn Sci"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.12.1342"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/13554794.2010.532138"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.20105"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13515"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5324.376"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1233756100"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2012.655781"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2004.05.018"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.08.042"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-10-02950.1986"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.22153","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.22153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hipo.22153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.22153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T14:41:36Z","timestamp":1696516896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.22153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,5]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/hipo.22153"],"URL":"https:\/\/doi.org\/10.1002\/hipo.22153","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,5]]}}}