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We investigated whether escalating doses of the cannabinoid receptor 1 (CB\n                    <jats:sub>1<\/jats:sub>\n                    R) agonist, HU\u2010210, in adolescence would affect adult hippocampal neurogenesis and behavioral processes putatively modulated by hippocampal neurogenesis, in adult male and female Sprague\u2010Dawley rats. Escalating doses of HU\u2010210 (25, 50, and 100 \u00b5g\/kg), or vehicle were administered from postnatal day (PND) 35 to 46. Animals were left undisturbed until PND 70, when they were treated with 5\u2010bromo\u20102\u2010deoxyuridine (BrdU; 200 mg\/kg) and perfused 21 days later to examine density of BrdU\u2010ir and BrdU\/NeuN cells in the dentate gyrus. In another cohort, hypothalamic\u2010pituitary\u2010adrenal (HPA) axis reactivity to an acute restraint stress (30 min; PND 75) and behavioral sensitization to d\u2010amphetamine sulfate (1\u20102 mg\/kg; PND 105\u2010134) were assessed in adulthood. Adolescent HU\u2010210 administration suppressed the density of BrdU\u2010ir cells in the dentate gyrus in adult male, but not adult female rats. Adolescent HU\u2010210 administration also induced significantly higher peak corticosterone levels and reminiscent of the changes in neurogenesis, this effect was more pronounced in adult males than females. However, adolescent cannabinoid treatment resulted in significantly higher stereotypy scores in adult female, but not male, rats. Thus, adolescent CB\n                    <jats:sub>1<\/jats:sub>\n                    R activation suppressed hippocampal neurogenesis and increased stress responsivity in adult males, but not females, and enhanced amphetamine sensitization in adult female, but not male, rats. Taken together, increased CB\n                    <jats:sub>1<\/jats:sub>\n                    R activation during adolescence results in sex\u2010dependent, long\u2010term, changes to hippocampal structure and function, an effect that may shed light on differing vulnerabilities to developing disorders following adolescent cannabinoid exposure, based on sex. \u00a9 2013 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/hipo.22221","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T15:38:48Z","timestamp":1381937928000},"page":"280-292","source":"Crossref","is-referenced-by-count":50,"title":["Sex, drugs, and adult neurogenesis: Sex\u2010dependent effects of escalating adolescent cannabinoid exposure on adult hippocampal neurogenesis, stress reactivity, and amphetamine sensitization"],"prefix":"10.1002","volume":"24","author":[{"given":"Tiffany T.\u2010Y.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of 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B.","family":"Gorzalka","sequence":"additional","affiliation":[{"name":"Department of Psychology University of British Columbia, Vancouver, BC, Canada"},{"name":"Program in Neuroscience, University of British Columbia, Vancouver BC 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