{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:24:12Z","timestamp":1768638252797,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Despite the well documented role of the hippocampus in various modes of drug reinstatement behavior, the persisting effects of <jats:italic>in vivo<\/jats:italic> cocaine exposure on hippocampal synaptic plasticity are not sufficiently understood. In this report we investigated the effects of cocaine conditioning on long\u2010term potentiation (LTP) in the CA1 region of hippocampus along its septotemporal axis. Male Sprague\u2010Dawley rats experienced a behavioral protocol, in which locomotor activity was monitored in response to various conditioning treatments. LTP was measured in <jats:italic>ex vivo<\/jats:italic> slice preparations taken 1\u20132 weeks after the last behavioral session from the ventral (vH) and dorsal (dH) sectors of hippocampus. Unexpectedly, experiencing the minor intermittent stimuli of the behavioral protocol caused stress\u2010induced metaplastic changes in both vH (increased LTP) and dH (decreased LTP) in the saline conditioned rats relative to behaviorally na\u00efve controls. These stress effects in the vH and dH were blocked by conditioning with either mineralocorticoid (spironolactone) or glucocorticoid (mifepristone) antagonists, respectively. Stress\u2010induced metaplasticity in the vH was also prevented by prior administration of the kappa opioid antagonist nor\u2010binaltorphimine. Cocaine conditioning induced locomotor sensitization and significantly increased LTP in the vH without causing significant change in LTP in the dH. Cocaine\u2010induced metaplasticity in the vH was prevented by co\u2010administration of the dopamine D<jats:sub>2\u2010like<\/jats:sub> antagonist eticlopride during cocaine conditioning, but not by co\u2010administration of the D<jats:sub>1\/5<\/jats:sub> antagonist SCH 23390. Our results suggest that the functional connectivity of hippocampus is altered by metaplastic triggers such as exposure to drugs of abuse and\/or stressors, thereby shifting the efferent output of hippocampus from dH (cortical) toward vH (limbic) influenced circuits. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22250","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T10:46:48Z","timestamp":1390819608000},"page":"577-590","source":"Crossref","is-referenced-by-count":37,"title":["Cocaine\u2010 or stress\u2010induced metaplasticity of LTP in the dorsal and ventral hippocampus"],"prefix":"10.1002","volume":"24","author":[{"given":"Madhusudhanan M.","family":"Keralapurath","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology University of Georgia Athens Georgia"},{"name":"Interdisciplinary Toxicology Program University of Georgia Athens Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason K.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Georgia Athens Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherri","family":"Hammond","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Georgia Athens Georgia"},{"name":"Neuroscience Program University of Georgia Athens Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Georgia Athens Georgia"},{"name":"Interdisciplinary Toxicology Program University of Georgia Athens Georgia"},{"name":"Neuroscience Program University of Georgia Athens Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.112.6.1327"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.09.040"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.07.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.110.4.661"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.242693"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)63015-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.11.031"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300579"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367780780937454"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227643"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.10.037"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.03.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.08.031"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890600678004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-19-07281.2003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8719(95)00025-D"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90193-Q"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204622"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0155-07.2007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.11.026"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2012.00012"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-13-05674.2003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.21.9697"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.9.74"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001446"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-001-0968-z"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.02.003"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)01002-2"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00080-7"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1122-y"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03990.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2007.01.003"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.01.038"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00021-7"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20751"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1224-x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02589.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2704997"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1844-5"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-32-10258.2003"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.49928"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.63806"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.05.001"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.03.005"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000493"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90275-1"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058043"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/29783"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.22250","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.22250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:26:29Z","timestamp":1696353989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.22250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,12]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1002\/hipo.22250"],"URL":"https:\/\/doi.org\/10.1002\/hipo.22250","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,12]]}}}