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We have detected the enzyme GNMT (a liver metabolic enzyme) in the hippocampus. GNMT regulates intracellular levels of SAMe, which is a universal methyl donor implied in almost all methylation reactions and, thus, of prime importance for DNA methylation. In addition, we show that deficiency of this enzyme in mice (Gnmt\u2212\/\u2212) results in high SAMe levels within the hippocampus, reduced neurogenic capacity, and spatial learning and memory impairment. In vitro, SAMe inhibited neural precursor cell division in a concentration\u2010dependent manner, but only when proliferation signals were triggered by bFGF. Indeed, SAMe inhibited the bFGF\u2010stimulated MAP kinase signaling cascade, resulting in decreased cyclin E expression. These results suggest that alterations in the concentration of SAMe impair neurogenesis and contribute to cognitive decline. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22274","type":"journal-article","created":{"date-parts":[[2014,3,29]],"date-time":"2014-03-29T09:24:53Z","timestamp":1396085093000},"page":"840-852","source":"Crossref","is-referenced-by-count":34,"title":["Glycine<i>N<\/i>\u2010methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance"],"prefix":"10.1002","volume":"24","author":[{"given":"Manuel","family":"Carrasco","sequence":"first","affiliation":[{"name":"Area de Fisiologia, Facultad de Medicina Universidad de C\u00e1diz, C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis G.","family":"Rabaneda","sequence":"additional","affiliation":[{"name":"Area de Fisiologia, Facultad de Medicina Universidad de C\u00e1diz, C\u00e1diz, 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