{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:20:00Z","timestamp":1791087600122,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T00:00:00Z","timestamp":1398816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Autism is a complex neurodevelopmental disorder with high heritability. <jats:italic>grik2<\/jats:italic> (which encodes the GluK2 subunit of kainate receptors) has been identified as a susceptibility gene in Autism Spectrum Disorders (ASD), but its role in the core and associated symptoms of ASD still remains elusive. We used mice lacking GluK2 (GluK2 KO) to examine their endophenotype with a view to modeling aspects of autism, including social deficits, stereotyped and repetitive behavior and decreased cognitive abilities. Anxiety was recorded in the elevated plus maze, social behavior in a three\u2010chamber apparatus, and cognition in different water maze protocols. Deletion of the GluK2 gene reduced locomotor activity and sociability as indicated by the social interaction task. In addition, GluK2 KO mice learnt to locate a hidden platform in a water maze surrounded by a curtain with hanging cues faster than wild\u2010type mice. They maintained a bias toward the target quadrant when some of these cues were removed, at which point wild\u2010types orthogonalized the behavior and showed no memory. However, GluK2 KO mice were impaired in spatial reversal learning. These behavioral data together with previously published electrophysiology showing severe anomalies in CA3 network activity, suggest a computational shift in this network for enhanced propensity of pattern completion that would explain the loss of behavioral flexibility in GluK2 KO mice. Although a single mutation cannot recapitulate the entire core symptoms of ASD, our data provide evidence for glutamatergic dysfunction underlying a number of social\u2010 and cognition\u2010related phenotypes relevant to ASD. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22290","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T04:44:49Z","timestamp":1397796289000},"page":"1059-1069","source":"Crossref","is-referenced-by-count":42,"title":["Impaired hippocampus\u2010dependent spatial flexibility and sociability represent autism\u2010like phenotypes in GluK2 mice"],"prefix":"10.1002","volume":"24","author":[{"given":"Jacques","family":"Micheau","sequence":"first","affiliation":[{"name":"Institut de Neurosciences Cognitives et Int\u00e9gratives d'Aquitaine Universit\u00e9 de Bordeaux, CNRS UMR 5287 33 405 Talence Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Vimeney","sequence":"additional","affiliation":[{"name":"Institut Interdisciplinaire de Neurosciences Universit\u00e9 de Bordeaux, CNRS UMR 5297 146 rue L\u00e9o\u2010Saignat 33077 Bordeaux Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Normand","sequence":"additional","affiliation":[{"name":"Institut Interdisciplinaire de Neurosciences Universit\u00e9 de Bordeaux, CNRS UMR 5297 146 rue L\u00e9o\u2010Saignat 33077 Bordeaux Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Mulle","sequence":"additional","affiliation":[{"name":"Institut Interdisciplinaire de Neurosciences Universit\u00e9 de Bordeaux, CNRS UMR 5297 146 rue L\u00e9o\u2010Saignat 33077 Bordeaux Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Riedel","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of Aberdeen, Foresterhill Aberdeen AB25 2ZD United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01463-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00011-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1065"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301312"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970324)379:4<541::AID-CNE6>3.0.CO;2-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.03.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.02.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2003.08.015"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-1094-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.12.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00191-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00096.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.05.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-007-9193-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.175"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2011.04153.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.11.003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.69"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201100157"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.02.012"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000979"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2007.03.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4059-04.2005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135801"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.703907"},{"key":"e_1_2_7_27_1","first-page":"1","volume-title":"Neuroscience and Connectionist Theory","author":"McNaughton BL","year":"1990"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32833782d4"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.7.945"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/521275"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/33408"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2004.00071.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071795"},{"issue":"12","key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1176\/ajp.2006.163.12.2189","article-title":"In vivo 1H\u2010magnetic resonance spectroscopy study of amygdala\u2010hippocampal and parietal regions in autism","volume":"163","author":"Page LA","year":"2006","journal-title":"Am J Psychiatry"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.5.805"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.06.012"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5807-08.2009"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30374"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1285-06.2006"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.20"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30025"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2851"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097675"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53860-4.00009-X"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2010.05.007"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.450040319"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(00)00405-4"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3812-11.2012"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20041"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00673-2"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.06.023"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6107-11.2012"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101567108"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.06.006"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.22290","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.22290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:19:55Z","timestamp":1696353595000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.22290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,30]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1002\/hipo.22290"],"URL":"https:\/\/doi.org\/10.1002\/hipo.22290","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,30]]}}}