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There is no accepted pharmacological treatment for AN, and AN has the highest mortality rate among psychiatric illnesses. Anorexia nervosa most commonly affects females during adolescence, suggesting an effect of sex and hormones on vulnerability to the disease. Activity\u2010based anorexia (ABA) is a rodent model of AN that shares symptoms with AN, including over\u2010exercise, elevation of stress hormones, and genetic links to anxiety traits. We previously reported that ABA in adolescent female rats results in increased apical dendritic branching in CA1 pyramidal cells of the ventral hippocampus at postnatal day 44 (P44). To examine the long\u2010term effects of adolescent ABA (P44) in female rats, we compared the apical branching in the ventral hippocampal CA1 after recovery from ABA (P51) and after a relapse of ABA (P55) with age\u2010matched controls. To examine the age\u2010dependence of the hippocampal plasticity, we examined the effect of ABA during adulthood (P67). We found that while ABA at P44 resulted in increased branching of ventral hippocampal pyramidal cells, relapse of ABA at P55 resulted in decreased branching. ABA induced during adulthood did not have an effect on dendritic branching, suggesting an age\u2010dependence of the vulnerability to structural plasticity. Cells from control animals were found to exhibit a dramatic increase in branching, more than doubling from P44 to P51, followed by pruning from P51 to P55. The proportion of mature spines on dendrites from the P44\u2010ABA animals is similar to that on dendrites from P55\u2010CON animals. These results suggest that the experience of ABA may cause precocious anatomical development of the ventral hippocampus. Importantly, we found that adolescence is a period of continued development of the hippocampus, and increased vulnerability to mental disorders during adolescence may be due to insults during this developmentally critical period. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22320","type":"journal-article","created":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T09:11:30Z","timestamp":1403946690000},"page":"1421-1429","source":"Crossref","is-referenced-by-count":47,"title":["Activity\u2010based anorexia during adolescence disrupts normal development of the CA1 pyramidal cells in the ventral hippocampus of female rats"],"prefix":"10.1002","volume":"24","author":[{"given":"Tara G.","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Center for Neural Science New York University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariel B.","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Center for Neural Science New York University New York New York"},{"name":"Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology The Rockefeller University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Chan","sequence":"additional","affiliation":[{"name":"Center for Neural Science New York University New York New York"},{"name":"Graduate School of Biomedical Sciences Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela S.","family":"Cassataro","sequence":"additional","affiliation":[{"name":"Center for Neural Science New York University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.","family":"Barbarich\u2010Marsteller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Physicians and Surgeons of Columbia University New York New York"},{"name":"Department of Psychiatry New York State Psychiatric Institute New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiye","family":"Aoki","sequence":"additional","affiliation":[{"name":"Center for Neural Science New York University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90424-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300528"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.116.5.884"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.10.014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.3.305"},{"key":"e_1_2_6_7_1","article-title":"Activity\u2010based anorexia has differential effects on apical dendritic branching in dorsal and ventral hippocampal 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