{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:03:52Z","timestamp":1790424232865,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":341,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS-065027"],"award-info":[{"award-number":["NS-065027"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS-40593"],"award-info":[{"award-number":["NS-40593"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001819","name":"International Rett Syndrome Foundation","doi-asserted-by":"publisher","award":["IRSF0804"],"award-info":[{"award-number":["IRSF0804"]}],"id":[{"id":"10.13039\/100001819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001819","name":"International Rett Syndrome Foundation","doi-asserted-by":"publisher","award":["IRSF2824"],"award-info":[{"award-number":["IRSF2824"]}],"id":[{"id":"10.13039\/100001819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS-47466"],"award-info":[{"award-number":["NS-47466"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1002\/hipo.22360","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T16:09:58Z","timestamp":1410365398000},"page":"159-168","source":"Crossref","is-referenced-by-count":128,"title":["Excitation\/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of<i>Mecp2<\/i>knockout mice"],"prefix":"10.1002","volume":"25","author":[{"given":"Gaston","family":"Calfa","sequence":"first","affiliation":[{"name":"Department of Neurobiology; Civitan International Research Center, The University of Alabama at Birmingham; Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurobiology; Civitan International Research Center, The University of Alabama at Birmingham; Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Department of Neurobiology; Civitan International Research Center, The University of Alabama at Birmingham; Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Pozzo-Miller","sequence":"additional","affiliation":[{"name":"Department of Neurobiology; Civitan International Research Center, The University of Alabama at Birmingham; Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,25]]},"reference":[{"key":"10.1002\/hipo.22360-BIB0001|hipo22360-cit-0001","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat Genet"},{"key":"10.1002\/hipo.22360-BIB0002|hipo22360-cit-0002","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1152\/jn.00800.2010","article-title":"Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging","volume":"105","author":"Calfa","year":"2011a","journal-title":"J Neurophysiol"},{"key":"10.1002\/hipo.22360-BIB0003|hipo22360-cit-0003","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1258\/ebm.2010.010261","article-title":"Experimental models of Rett syndrome based on Mecp2 dysfunction","volume":"236","author":"Calfa","year":"2011b","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1002\/hipo.22360-BIB0004|hipo22360-cit-0004","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.seizure.2011.06.010","article-title":"Epilepsy in Rett syndrome: Association between phenotype and genotype, and implications for practice","volume":"20","author":"Cardoza","year":"2011","journal-title":"Seizure"},{"key":"10.1002\/hipo.22360-BIB0005|hipo22360-cit-0005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2005.12.027","article-title":"The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression","volume":"49","author":"Chang","year":"2006","journal-title":"Neuron"},{"key":"10.1002\/hipo.22360-BIB0006|hipo22360-cit-0006","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2007.08.018","article-title":"MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number","volume":"56","author":"Chao","year":"2007","journal-title":"Neuron"},{"key":"10.1002\/hipo.22360-BIB0007|hipo22360-cit-0007","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nature09582","article-title":"Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes","volume":"468","author":"Chao","year":"2010","journal-title":"Nature"},{"key":"10.1002\/hipo.22360-BIB0008|hipo22360-cit-0008","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"Chen","year":"2001","journal-title":"Nat Genet"},{"key":"10.1002\/hipo.22360-BIB0009|hipo22360-cit-0009","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nature711","article-title":"Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1","volume":"415","author":"Costa","year":"2002","journal-title":"Nature"},{"key":"10.1002\/hipo.22360-BIB0010|hipo22360-cit-0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.nbd.2009.12.018","article-title":"Alterations of cortical and hippocampal EEG activity in MeCP2-deficient mice","volume":"38","author":"D'Cruz","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1002\/hipo.22360-BIB0011|hipo22360-cit-0011","doi-asserted-by":"crossref","first-page":"11263","DOI":"10.1523\/JNEUROSCI.1019-09.2009","article-title":"Intact long-term potentiation but reduced connectivity between neocortical layer 5 pyramidal neurons in a mouse model of Rett syndrome","volume":"29","author":"Dani","year":"2009","journal-title":"J Neurosci"},{"key":"10.1002\/hipo.22360-BIB0012|hipo22360-cit-0012","doi-asserted-by":"crossref","first-page":"12560","DOI":"10.1073\/pnas.0506071102","article-title":"Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome","volume":"102","author":"Dani","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hipo.22360-BIB0013|hipo22360-cit-0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0004.2007.00822.x","article-title":"Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders","volume":"72","author":"Cristo","year":"2007","journal-title":"Clin Genet"},{"key":"10.1002\/hipo.22360-BIB0014|hipo22360-cit-0014","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.neuron.2012.12.004","article-title":"NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2","volume":"76","author":"Durand","year":"2012","journal-title":"Neuron"},{"key":"10.1002\/hipo.22360-BIB0015|hipo22360-cit-0015","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.neuron.2008.12.007","article-title":"Reversing neurodevelopmental disorders in adults","volume":"60","author":"Ehninger","year":"2008","journal-title":"Neuron"},{"key":"10.1002\/hipo.22360-BIB0016|hipo22360-cit-0016","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nn1860","article-title":"Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome","volume":"10","author":"Fernandez","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1002\/hipo.22360-BIB0017|hipo22360-cit-0017","doi-asserted-by":"crossref","first-page":"e56311","DOI":"10.1371\/journal.pone.0056311","article-title":"Synaptic competition sculpts the development of GABAergic axo-dendritic but not perisomatic synapses","volume":"8","author":"Frola","year":"2013","journal-title":"PLoS One"},{"key":"10.1002\/hipo.22360-BIB0018|hipo22360-cit-0018","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1152\/jn.90752.2008","article-title":"Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome","volume":"100","author":"Gibson","year":"2008","journal-title":"J Neurophysiol"},{"key":"10.1002\/hipo.22360-BIB0019|hipo22360-cit-0019","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archneur.1987.00520220051016","article-title":"Rett's syndrome. Correlation of electroencephalographic characteristics with clinical staging","volume":"44","author":"Glaze","year":"1987","journal-title":"Arch Neurol"},{"key":"10.1002\/hipo.22360-BIB0020|hipo22360-cit-0020","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuroscience.2013.01.008","article-title":"Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain","volume":"236","author":"Hortnagl","year":"2013","journal-title":"Neuroscience"},{"key":"10.1002\/hipo.22360-BIB0021|hipo22360-cit-0021","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1523\/JNEUROSCI.1766-04.2004","article-title":"Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome","volume":"24","author":"Kleschevnikov","year":"2004","journal-title":"J Neurosci"},{"key":"10.1002\/hipo.22360-BIB0022|hipo22360-cit-0022","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1523\/JNEUROSCI.5503-09.2010","article-title":"Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice","volume":"30","author":"Kline","year":"2010","journal-title":"J Neurosci"},{"key":"10.1002\/hipo.22360-BIB0023|hipo22360-cit-0023","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1523\/JNEUROSCI.1943-07.2007","article-title":"A local reduction in cortical GABAergic synapses after a loss of endogenous brain-derived neurotrophic factor, as revealed by single-cell gene knock-out method","volume":"27","author":"Kohara","year":"2007","journal-title":"J Neurosci"},{"key":"10.1002\/hipo.22360-BIB0024|hipo22360-cit-0024","doi-asserted-by":"crossref","first-page":"13860","DOI":"10.1523\/JNEUROSCI.2159-12.2012","article-title":"Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment","volume":"32","author":"Kron","year":"2012","journal-title":"J Neurosci"},{"key":"10.1002\/hipo.22360-BIB0025|hipo22360-cit-0025","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.tins.2003.09.007","article-title":"Interneuron diversity series: Containing the detonation--feedforward inhibition in the CA3 hippocampus","volume":"26","author":"Lawrence","year":"2003","journal-title":"Trends Neurosci"},{"issue":"Part C","key":"10.1002\/hipo.22360-BIB0026|hipo22360-cit-0026","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuropharm.2013.03.024","article-title":"BDNF deregulation in Rett syndrome","volume":"76","author":"Li","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1002\/hipo.22360-BIB0027|hipo22360-cit-0027","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.cub.2005.09.043","article-title":"The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1","volume":"15","author":"Li","year":"2005","journal-title":"Curr Biol"},{"key":"10.1002\/hipo.22360-BIB0028|hipo22360-cit-0028","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1152\/jn.00826.2007","article-title":"Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome","volume":"99","author":"Medrihan","year":"2008","journal-title":"J Neurophysiol"},{"key":"10.1002\/hipo.22360-BIB0029|hipo22360-cit-0029","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.cub.2006.02.062","article-title":"MeCP2-dependent transcriptional repression regulates excitatory neurotransmission","volume":"16","author":"Nelson","year":"2006","journal-title":"Curr Biol"},{"key":"10.1002\/hipo.22360-BIB0030|hipo22360-cit-0030","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1152\/jn.00751.2010","article-title":"Selective impact of MeCP2 and associated histone deacetylases on the dynamics of evoked excitatory neurotransmission","volume":"106","author":"Nelson","year":"2011","journal-title":"J Neurophysiol"},{"key":"10.1002\/hipo.22360-BIB0031|hipo22360-cit-0031","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1528-1167.2010.02597.x","article-title":"Epilepsy in Rett syndrome-The experience of a National Rett Center","volume":"51","author":"Nissenkorn","year":"2010","journal-title":"Epilepsia"},{"key":"10.1002\/hipo.22360-BIB0032|hipo22360-cit-0032","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuron.2011.03.001","article-title":"Experience-dependent retinogeniculate synapse remodeling is abnormal in MeCP2-deficient mice","volume":"70","author":"Noutel","year":"2011","journal-title":"Neuron"},{"key":"10.1002\/hipo.22360-BIB0033|hipo22360-cit-0033","doi-asserted-by":"crossref","first-page":"10912","DOI":"10.1523\/JNEUROSCI.1869-07.2007","article-title":"Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome","volume":"27","author":"Ogier","year":"2007","journal-title":"J Neurosci"},{"key":"10.1002\/hipo.22360-BIB0034|hipo22360-cit-0034","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/brain\/awl022","article-title":"Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice","volume":"129","author":"Pelka","year":"2006","journal-title":"Brain"},{"key":"10.1002\/hipo.22360-BIB0035|hipo22360-cit-0035","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.yebeh.2010.06.051","article-title":"Epilepsy in Rett syndrome: Clinical and genetic features","volume":"19","author":"Pintaudi","year":"2010","journal-title":"Epilepsy Behav"},{"key":"10.1002\/hipo.22360-BIB0036|hipo22360-cit-0036","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/bioinformatics\/btp184","article-title":"Globally optimal stitching of tiled 3D microscopic image acquisitions","volume":"25","author":"Preibisch","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1002\/hipo.22360-BIB0037|hipo22360-cit-0037","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1034\/j.1601-183X.2003.00037.x","article-title":"Model of autism: Increased ratio of excitation\/inhibition in key neural systems","volume":"2","author":"Rubenstein","year":"2003","journal-title":"Genes Brain Behav"},{"key":"10.1002\/hipo.22360-BIB0038|hipo22360-cit-0038","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neulet.2007.12.039","article-title":"Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome","volume":"433","author":"Rueda","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1002\/hipo.22360-BIB0039|hipo22360-cit-0039","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1523\/JNEUROSCI.0865-11.2012","article-title":"A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome","volume":"32","author":"Schmid","year":"2012","journal-title":"J Neurosci"},{"key":"10.1002\/hipo.22360-BIB0040|hipo22360-cit-0040","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(02)00768-7","article-title":"Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3","volume":"35","author":"Shahbazian","year":"2002","journal-title":"Neuron"},{"key":"10.1002\/hipo.22360-BIB0041|hipo22360-cit-0041","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.conb.2011.06.006","article-title":"Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: Focus on Mecp2 and Met","volume":"21","author":"Shepherd","year":"2011","journal-title":"Curr Opin Neurobiol"},{"key":"10.1002\/hipo.22360-BIB0042|hipo22360-cit-0042","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1651-2227.2001.tb00252.x","article-title":"Epilepsy in a representative series of Rett syndrome","volume":"90","author":"Steffenburg","year":"2001","journal-title":"Acta Paediatr"},{"key":"10.1002\/hipo.22360-BIB0043|hipo22360-cit-0043","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1523\/JNEUROSCI.5390-08.2009","article-title":"Functional specificity of mossy fiber innervation of GABAergic cells in the hippocampus","volume":"29","author":"Szabadics","year":"2009","journal-title":"J Neurosci"},{"key":"10.1002\/hipo.22360-BIB0044|hipo22360-cit-0044","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nrn988","article-title":"Role of neurotrophins in central synapse formation and stabilization","volume":"3","author":"Vicario-Abejon","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"10.1002\/hipo.22360-BIB0045|hipo22360-cit-0045","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/hipo.20389","article-title":"The MeCP2-null mouse hippocampus displays altered basal inhibitory rhythms and is prone to hyperexcitability","volume":"18","author":"Zhang","year":"2008","journal-title":"Hippocampus"},{"key":"10.1002\/hipo.22360-BIB0046|hipo22360-cit-0046","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1152\/jn.00601.2009","article-title":"MeCP2 is required for normal development of GABAergic circuits in the thalamus","volume":"103","author":"Zhang","year":"2010","journal-title":"J Neurophysiol"},{"key":"10.1002\/hipo.22360-BIB0047|hipo22360-cit-0047","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1523\/JNEUROSCI.4900-12.2014","article-title":"Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures","volume":"34","author":"Zhang","year":"2014","journal-title":"J Neurosci"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.22360","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/hipo.22360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T23:00:12Z","timestamp":1625266812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.22360"}},"subtitle":["E\/I Imbalance In Mecp2 Knockout Hippocampus"],"short-title":[],"issued":{"date-parts":[[2014,9,25]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"URL":"https:\/\/doi.org\/10.1002\/hipo.22360","relation":{},"ISSN":["1050-9631"],"issn-type":[{"value":"1050-9631","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9,25]]}}}