{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:03:43Z","timestamp":1775801023209,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CNPq (universal)","award":["478115\/2010-5"],"award-info":[{"award-number":["478115\/2010-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Recently, we have described the influence of dietary fatty acids (FA) on mania\u2010like behavior of first generation animals. Here, two sequential generations of female rats were supplemented with soybean oil (SO, rich in n\u20106 FA, control group), fish oil (FO, rich in n\u20103 FA) and hydrogenated vegetable fat (HVF, rich in trans FA) from pregnancy and during lactation. In adulthood, half of each group was exposed to an amphetamine (AMPH)\u2010induced mania animal model for behavioral, biochemical and molecular assessments. FO supplementation was associated with lower reactive species (RS) generation and protein carbonyl (PC) levels and increased dopamine transporter (DAT) levels, while HVF increased RS and PC levels, thus decreasing catalase (CAT) activity and DAT levels in hippocampus after AMPH treatment. AMPH impaired short\u2010 (1 h) and long\u2010 (24 h) term memory in the HVF group. AMPH exposure was able to reduce hippocampal BDNF\u2010 mRNA expression, which was increased in FO. While HVF was related to higher <jats:italic>trans<\/jats:italic> FA (TFA) incorporation in hippocampus, FO was associated with increased percentage of n\u20103 polyunsaturated FA (PUFA) together with lower n\u20106\/n\u20103 PUFA ratio. Interestingly, our data showed a positive correlation between brain\u2010derived neurotrophic factor (BDNF) mRNA and short\u2010 and long\u2010term memory (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.53; <jats:italic>P<\/jats:italic>\u2009=\u20090.000\/<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.32; <jats:italic>P<\/jats:italic>\u2009=\u20090.011, respectively), as well as a negative correlation between PC and DAT levels (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.23; <jats:italic>P<\/jats:italic>\u2009=\u20090.015). Our findings confirm that provision of n\u20103 or TFA during development over two generations is able to change the neuronal membrane lipid composition, protecting or impairing the hippocampus, respectively, thus affecting neurothrophic factor expression such as BDNF mRNA. In this context, chronic consumption of <jats:italic>trans<\/jats:italic> fats over two generations can facilitate the development of mania\u2010like behavior, so leading to memory impairment and emotionality, which are related to neuropsychiatric conditions. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22391","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T09:48:26Z","timestamp":1415958506000},"page":"556-565","source":"Crossref","is-referenced-by-count":18,"title":["Cross\u2010generational <i>trans<\/i> fat intake modifies <scp>BDNF<\/scp> m<scp>RNA<\/scp> in the hippocampus: Impact on memory loss in a mania animal model"],"prefix":"10.1002","volume":"25","author":[{"given":"Fab\u00edola","family":"Trevizol","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia\u2010Universidade Federal de Santa Maria(UFSM)\u2010RS  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f4nica T.","family":"Dias","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia\u2010 UFSM\u2010RS  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katiane","family":"Roversi","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia\u2010 UFSM\u2010RS  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel C.S.","family":"Barcelos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia\u2010Universidade Federal de Santa Maria(UFSM)\u2010RS  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio T.","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia\u2010Universidade Federal de Santa Maria(UFSM)\u2010RS  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