{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:47:18Z","timestamp":1791262038077,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Converging evidence indicates that pharmacologically elevating histone acetylation using post\u2010training, systemic or intrahippocampal, administration of histone deacetylase inhibitor (HDACi) can enhance memory consolidation processes in young rodents but it is not yet clear, whether such treatment is sufficient to prevent memory impairments associated with aging. To address this question, we used a 1\u2010day massed spatial learning task in the water maze to investigate the effects of immediate post\u2010training injection of the HDACi trichostatin A (TSA) into the dorsal hippocampus on long\u2010term memory consolidation in 3\u20134 and 18\u201320 month\u2010old mice. We show that TSA improved the 24 h\u2010memory retention for the hidden platform location in young\u2010adults, but failed to rescue memory impairments in older mice. The results further indicate that Young\u2010TSA mice sacrificed 1 h after training had a robust increase in histone H4 acetylation in the dorsal hippocampal CA1 region (dCA1) and the dorsomedial part of the striatum (DMS), a structure important for spatial information processing. Importantly, TSA infusion in aged mice completely rescued altered H4 acetylation in the dCA1 but failed to alleviate age\u2010associated decreased H4 acetylation in the DMS. Moreover, intrahippocampal TSA infusion produced concomitant decreases (in adults) or increases (in older mice) of acetylated histone levels in the ventral hippocampus (vCA1 and vCA3) and the lateral amygdala, two structures critically involved in stress and emotional responses. These data suggest that the failure of post\u2010training, intrahippocampal TSA injection to reverse age\u2010associated memory impairments may be related to an inability to recruit appropriate circuit\u2010specific epigenetic patterns during early consolidation processes. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22406","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T04:28:10Z","timestamp":1419049690000},"page":"827-837","source":"Crossref","is-referenced-by-count":20,"title":["Post\u2010training, intrahippocampal HDAC inhibition differentially impacts neural circuits underlying spatial memory in adult and aged mice"],"prefix":"10.1002","volume":"25","author":[{"given":"Malorie","family":"Dagnas","sequence":"first","affiliation":[{"name":"Institut de Neurosciences Cognitives et Int\u00e9gratives d'Aquitaine, CNRS UMR 5287, Universit\u00e9 de Bordeaux, Avenue des Facult\u00e9s 33405 Talence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Micheau","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences Cognitives et Int\u00e9gratives d'Aquitaine, CNRS UMR 5287, Universit\u00e9 de Bordeaux, Avenue des Facult\u00e9s 33405 Talence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Decorte","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences Cognitives et Int\u00e9gratives d'Aquitaine, CNRS UMR 5287, Universit\u00e9 de Bordeaux, Avenue des Facult\u00e9s 33405 Talence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Beracochea","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences Cognitives et Int\u00e9gratives d'Aquitaine, CNRS UMR 5287, Universit\u00e9 de Bordeaux, Avenue des Facult\u00e9s 33405 Talence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Mons","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences Cognitives et Int\u00e9gratives d'Aquitaine, CNRS UMR 5287, Universit\u00e9 de Bordeaux, Avenue des Facult\u00e9s 33405 Talence France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01687.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.9.5280"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2011.00014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2014.02.009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.117"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057816"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033249"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22286"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22116"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3453-12.2013"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.06.028"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.05.019"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020225"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-07-02789.1999"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2334169100"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1537009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.259206"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05772"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.09.003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1134"},{"key":"e_1_2_6_22_1","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin KBJ","year":"1997"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2010"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1986911"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.2097411"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64145"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2014.02.005"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.08.040"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.197"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00001"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22181"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.121.5.1125"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402229200"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00741.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-18-07535.1998"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-09-03916.1993"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.64803"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.656907"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1186088"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1094208"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.03.033"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.229"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5717-09.2010"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2012.12.001"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.12.012"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903964106"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2009.11.009"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0296-07.2007"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217832110"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03095.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3878-11.2011"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.22406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.22406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T13:14:13Z","timestamp":1696598053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.22406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,27]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/hipo.22406"],"URL":"https:\/\/doi.org\/10.1002\/hipo.22406","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,27]]}}}