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The LC releases noradrenaline in response to novel experience and LC activation leads to an enhancement of hippocampus\u2010based learning, and facilitates synaptic plasticity in the form of long\u2010term depression (LTD) and long\u2010term potentiation (LTP) that occur in association with spatial learning. The predominant receptor for mediating these effects is the \u03b2\u2010adrenoreceptor. Interestingly, the dependency of synaptic plasticity on this receptor is different in the hippocampal subfields whereby in the CA1 in vivo, LTP, but not LTD requires \u03b2\u2010adrenoreceptor activation, whereas in the mossy fiber synapse LTP and LTD do not depend on this receptor. By contrast, synaptic plasticity that is facilitated by spatial learning is highly dependent on \u03b2\u2010adrenoreceptor activation in both hippocampal subfields. Here, we explored whether LTP induced by perforant\u2010path (pp) stimulation in vivo or that is facilitated by spatial learning depends on \u03b2\u2010adrenoreceptors. We found that under both LTP conditions, antagonising the receptors disabled the persistence of LTP. \u03b2\u2010adrenoreceptor\u2010antagonism also prevented spatial learning. Strikingly, activation of the LC before high\u2010frequency stimulation (HFS) of the pp prevented short\u2010term potentiation but not LTP, and LC stimulation after pp\u2010HFS\u2010induced depotentiation of LTP. This depotentiation was prevented by \u03b2\u2010adrenoreceptor\u2010antagonism. These data suggest that \u03b2\u2010adrenoreceptor\u2010activation, resulting from noradrenaline release from the LC during enhanced arousal and learning, comprises a mechanism whereby the duration and degree of LTP is regulated and fine tuned. This may serve to optimize the creation of a spatial memory engram by means of LTP and LTD. This process can be expected to support the special role of the dentate gyrus as a crucial subregional locus for detecting and processing novelty within the hippocampus. \u00a9 2015 The Authors Hippocampus Published by Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22436","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T18:23:06Z","timestamp":1425061386000},"page":"1285-1298","source":"Crossref","is-referenced-by-count":96,"title":["Hippocampal long\u2010term potentiation that is elicited by perforant path stimulation or that occurs in conjunction with spatial learning is tightly controlled by beta\u2010adrenoreceptors and the locus coeruleus"],"prefix":"10.1002","volume":"25","author":[{"given":"Niels","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Neurophysiology Medical Faculty, Ruhr University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Manahan\u2010Vaughan","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology Medical Faculty, Ruhr University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91211-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2004.08.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.061604.135709"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/363347a0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1973.sp010274"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1973.sp010273"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1996.8.1.85"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890130303"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199702100-00028"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.09.013"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1057"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.09.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4307-04.2005"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2013.00088"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.209379"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.026898.112"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21758"},{"key":"e_1_2_6_20_1","first-page":"491","article-title":"Action of norepinephrine in the dentate gyrus. 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