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By adapting the transitivity paradigm<\/jats:bold>(Bunsey and Eichenbaum (1996) Nature 379:255\u2010257)<jats:bold>, which traditionally has been used in nonhuman animal research, this work examined the extent to which aging is accompanied by deficits in relational learning and flexible expression of relational information. Older adults' performance was additionally contrasted with that of amnesic case DA to understand the critical contributions of the medial temporal lobe, and specifically, the hippocampus, which endures structural and functional changes in healthy aging. Participants were required to select the correct choice item (B versus Y) based on the presented sample item (e.g., A). Pairwise relations must be learned (A\u2010&gt;B, B\u2010&gt;C, C\u2010&gt;D) so that ultimately, the correct relations can be inferred when presented with a novel probe item (A\u2010&gt;C?Z?). Participants completed four conditions of transitivity that varied in terms of the degree to which the stimuli and the relations among them were known pre\u2010experimentally. Younger adults, older adults, and DA performed similarly when the condition employed all pre\u2010experimentally known, semantic, relations. Older adults and DA were less accurate than younger adults when all to\u2010be\u2010learned relations were arbitrary. However, accuracy improved for older adults when they could use pre\u2010experimentally known pairwise relations to express understanding of arbitrary relations as indexed through inference judgments. DA could not learn arbitrary relations nor use existing knowledge to support novel inferences. These results suggest that while aging has often been associated with an emerging decline in hippocampal function, prior knowledge can be used to support novel inferences. However, in case DA, significant damage to the hippocampus likely impaired his ability to learn novel relations, while additional damage to ventromedial prefrontal and anterior temporal regions may have resulted in an inability to use prior knowledge to flexibly express indirect relational knowledge.<\/jats:bold>\u00a9 2015 The Authors Hippocampus Published by Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22501","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T08:44:58Z","timestamp":1438418698000},"page":"170-184","source":"Crossref","is-referenced-by-count":26,"title":["Relational learning and transitive expression in aging and amnesia"],"prefix":"10.1002","volume":"26","author":[{"given":"Jennifer D.","family":"Ryan","sequence":"first","affiliation":[{"name":"Rotman Research Institute Baycrest, Toronto Ontario Canada"},{"name":"Department of Psychology The University of Toronto Toronto Ontario Canada"},{"name":"Department of Psychiatry The University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Rotman Research Institute Baycrest, Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Kamino","sequence":"additional","affiliation":[{"name":"Rotman Research Institute Baycrest, Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Ostreicher","sequence":"additional","affiliation":[{"name":"Rotman Research Institute Baycrest, Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra N.","family":"Moses","sequence":"additional","affiliation":[{"name":"Rotman Research Institute Baycrest, Toronto Ontario Canada"},{"name":"Department of Diagnostic Imaging and Neurosciences and Mental Health Hospital for Sick Children"},{"name":"Department of Medical Imaging University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Shayna","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Rotman Research Institute Baycrest, Toronto Ontario Canada"},{"name":"Department of Psychology York University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1742-06.2006"},{"key":"e_1_2_6_3_1","unstructured":"F.C Bartlett 1932 Cambridge University Press Cambridge UK"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/03610730500326291"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/379255a0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.20.4.718"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.18.4.873"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.034"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj112"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh211"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg081"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3662-08.2008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10114"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.7.1156"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.119.4.863"},{"key":"e_1_2_6_17_1","first-page":"768","article-title":"Dual\u2010process models of associative recognition in young and older adults: Evidence from receiver operating characteristics","volume":"31","author":"Healy MR","year":"2005","journal-title":"J Exp Psychol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10189"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","unstructured":"HolyoakKJ.(2012).Analogy and relational reasoning. 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