{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:42:56Z","timestamp":1792082576891,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Aging","award":["R37-AG011230"],"award-info":[{"award-number":["R37-AG011230"]}]},{"name":"Wayne State University Graduate School"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The hippocampus is composed of distinct subfields: the four cornu ammonis areas (CA1\u2010CA4), dentate gyrus (DG), and subiculum. The few\n                    <jats:italic>in vivo<\/jats:italic>\n                    studies of human hippocampal subfields suggest that the extent of age differences in volume varies across subfields during healthy childhood development and aging. However, the associations between age and subfield volumes across the entire lifespan are unknown. Here, we used a high\u2010resolution imaging technique and manually measured hippocampal subfield and entorhinal cortex volumes in a healthy lifespan sample (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009202), ages 8\u201382 yrs. The magnitude of age differences in volume varied among the regions. Combined CA1\u20102 volume evidenced a negative linear association with age. In contrast, the associations between age and volumes of CA3\u2010DG and the entorhinal cortex were negative in mid\u2010childhood and attenuated in later adulthood. Volume of the subiculum was unrelated to age. The different magnitudes and patterns of age differences in subfield volumes may reflect dynamic microstructural factors and have implications for cognitive functions across the lifespan. \u00a9 2015 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/hipo.22517","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T05:13:00Z","timestamp":1439961180000},"page":"220-228","source":"Crossref","is-referenced-by-count":155,"title":["Age differences in hippocampal subfield volumes from childhood to late adulthood"],"prefix":"10.1002","volume":"26","author":[{"given":"Ana M.","family":"Daugherty","sequence":"first","affiliation":[{"name":"Institute of Gerontology, Wayne State University Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Bender","sequence":"additional","affiliation":[{"name":"Institute of Gerontology, Wayne State University Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naftali","family":"Raz","sequence":"additional","affiliation":[{"name":"Institute of Gerontology, Wayne State University Detroit Michigan"},{"name":"Psychology Department Wayne State University Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Ofen","sequence":"additional","affiliation":[{"name":"Institute of Gerontology, Wayne State University Detroit Michigan"},{"name":"Psychology Department Wayne State University Detroit Michigan"},{"name":"Department of Pediatrics School of Medicine, Wayne State University Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"37","volume-title":"The Hippocampus Book Oxford Neuroscience Series","author":"Amaral D","year":"2006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1162\/jcon_a_00435"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00476-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.11.008"},{"key":"e_1_2_7_6_1","first-page":"14","volume-title":"Quantitative Applications in the Social Sciences","author":"Carmines EG","year":"1979"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.216.3.r00au37672"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22640"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-54195-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402680101"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20193"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2147"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2699"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03661-3_1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.172.2.2748838"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.07.007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8365-7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.01.064"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000154"},{"key":"e_1_2_7_23_1","first-page":"82","volume-title":"Aging in Nonhuman Primates. 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