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It has been well established that contextual fear memory relies on the hippocampus for expression shortly after learning, but it becomes hippocampus\u2010independent at a later time point, a process called systems consolidation. This time\u2010dependent process correlates with the loss of memory precision. Here, we investigated whether training intensity predicts the gradual decay of hippocampal dependency to retrieve memory, and the quality of the contextual memory representation over time. We have found that training intensity modulates the progressive decay of hippocampal dependency and memory precision. Strong training intensity accelerates systems consolidation and memory generalization in a remarkable timeframe match. The mechanisms underpinning such process are triggered by glucocorticoid and noradrenaline released during training. These results suggest that the stress levels during emotional learning act as a switch, determining the fate of memory quality. Moderate stress will create a detailed memory, whereas a highly stressful training will develop a generic gist\u2010like memory. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22527","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T21:39:05Z","timestamp":1441229945000},"page":"362-371","source":"Crossref","is-referenced-by-count":58,"title":["The dynamic nature of systems consolidation: Stress during learning as a switch guiding the rate of the hippocampal dependency and memory quality"],"prefix":"10.1002","volume":"26","author":[{"given":"Lizeth K.","family":"Pedraza","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio De Neurobiologia Da Mem\u00f3ria Porto Alegre 91.501\u2010970 Brazil"},{"name":"Graduate Program in Neuroscience, Institute of Health Sciences Federal University of Rio Grande Do Sul Porto Alegre 90.046\u2010900 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo 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