{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:37:22Z","timestamp":1791625042875,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"am","delay-in-days":325,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T00:00:00Z","timestamp":1455580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["N0014\u201004\u20101\u2010005"],"award-info":[{"award-number":["N0014\u201004\u20101\u2010005"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Given the high prevalence rates of comorbidity of anxiety and depressive disorders, identifying a common neural pathway to both disorders is important not only for better diagnosis and treatment, but also for a more complete conceptualization of each disease. Hippocampal abnormalities have been implicated in anxiety and depression, separately; however, it remains unknown whether these abnormalities are also implicated in their comorbidity. Here we address this question by testing 32 adults with generalized anxiety disorder (15 GAD only and 17 comorbid MDD) and 25 healthy controls (HC) using multimodal MRI (structure, diffusion and functional) and automated hippocampal segmentation. We demonstrate that (i) abnormal microstructure of the CA1 and CA2\u20103 is associated with GAD\/MDD comorbidity and (ii) decreased anterior hippocampal reactivity in response to repetition of the threat cue is associated with GAD (with or without MDD comorbidity). In addition, mediation\u2010structural equation modeling (SEM) reveals that our hippocampal and dimensional symptom data are best explained by a model describing a significant influence of abnormal hippocampal microstructure on both anxiety and depression\u2014mediated through its impact on abnormal hippocampal threat processing. Collectively, our findings show a strong association between changes in hippocampal microstructure and threat processing, which together may present a common neural pathway to comorbidity of anxiety and depression. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22566","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:29:27Z","timestamp":1452212967000},"page":"545-553","source":"Crossref","is-referenced-by-count":94,"title":["Abnormal hippocampal structure and function in clinical anxiety and comorbid depression"],"prefix":"10.1002","volume":"26","author":[{"given":"Jiook","family":"Cha","sequence":"first","affiliation":[{"name":"Department of Psychiatry Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsafrir","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Psychology Stony Brook University Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inkyung","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Blair Simpson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Posner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilianne R.","family":"Mujica\u2010Parodi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Stony Brook University Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02294272"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20733"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00054-8"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318259e1c5"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.1020"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4868-13.2014"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051628398"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.100.3.316"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.03.001"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00203-8"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-440X(00)90140-8"},{"key":"e_1_2_3_14_1","unstructured":"FirstM SpitzerR GibbonM WilliamsJ.2002. 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