{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:08Z","timestamp":1786977968518,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01\u2010AA017449"],"award-info":[{"award-number":["5R01\u2010AA017449"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50\u2010AA022534"],"award-info":[{"award-number":["P50\u2010AA022534"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37\u2010AA015614"],"award-info":[{"award-number":["R37\u2010AA015614"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010CA118100"],"award-info":[{"award-number":["P30\u2010CA118100"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Prenatal alcohol exposure (PAE) results in fetal alcohol spectrum disorder (FASD), which is characterized by a wide range of cognitive and behavioral deficits that may be linked to impaired hippocampal function and adult neurogenesis. Preclinical studies in mouse models of FASD indicate that PAE markedly attenuates enrichment\u2010mediated increases in the number of adult\u2010generated hippocampal dentate granule cells (aDGCs), but whether synaptic activity is also affected has not been studied. Here, we utilized retroviral birth\u2010dating coupled with whole cell patch electrophysiological recordings to assess the effects of PAE on enrichment\u2010mediated changes in excitatory and inhibitory synaptic activity as a function of DGC age. We found that exposure to an enriched environment (EE) had no effect on baseline synaptic activity of 4\u2010 or 8\u2010week\u2010old aDGCs from control mice, but significantly enhanced the excitatory\/inhibitory ratio of synaptic activity in 8\u2010week\u2010old aDGCs from PAE mice. In contrast, exposure to EE significantly enhanced the excitatory\/inhibitory ratio of synaptic activity in older pre\u2010existing DGCs situated in the outer dentate granule cell layer (i.e., those generated during embryonic development; dDGCs) in control mice, an effect that was blunted in PAE mice. These findings indicate distinct electrophysiological responses of hippocampal DGCs to behavioral challenge based on cellular ontogenetic age, and suggest that PAE disrupts EE\u2010mediated changes in overall hippocampal network activity. These findings may have implications for future therapeutic targeting of hippocampal dentate circuitry in clinical FASD. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22588","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T04:27:31Z","timestamp":1458793651000},"page":"1078-1087","source":"Crossref","is-referenced-by-count":22,"title":["Prenatal alcohol exposure alters synaptic activity of adult hippocampal dentate granule cells under conditions of enriched environment"],"prefix":"10.1002","volume":"26","author":[{"given":"Kenta","family":"Kajimoto","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Fernando","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Allan","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyu","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center New Mexico"},{"name":"Department of Neurobiology and Behavior State University of New York at Stony Brook Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center New Mexico"},{"name":"Department of Neurobiology and Behavior State University of New York at Stony Brook Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Anna","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0022-3565(24)37227-1","article-title":"Prenatal ethanol exposure alters the modulation of the gamma\u2010aminobutyric acidA1 receptor\u2010gated chloride ion channel in adult rat offspring","volume":"284","author":"Allan AM","year":"1998","journal-title":"J Pharmacol Exp 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