{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:42:21Z","timestamp":1790836941069,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Memory and related cognitive functions are progressively impaired in a subgroup of individuals experiencing childhood adversity and stress. However, it is not possible to identify vulnerable individuals early, a crucial step for intervention. In this study, high\u2010resolution magnetic resonance imaging (MRI) and intra\u2010hippocampal diffusion tensor imaging (DTI) were employed to examine for structural signatures of cognitive adolescent vulnerabilities in a rodent model of early\u2010life adversity. These methods were complemented by neuroanatomical and functional assessments of hippocampal network integrity during adolescence, adulthood and middle\u2010age. The high\u2010resolution MRI identified selective loss of dorsal hippocampal volume, and intra\u2010hippocampal DTI uncovered disruption of dendritic structure, consistent with disrupted local connectivity, already during late adolescence in adversity\u2010experiencing rats. Memory deteriorated over time, and stunting of hippocampal dendritic trees was apparent on neuroanatomical analyses. Thus, disrupted hippocampal neuronal structure and connectivity, associated with cognitive impairments, are detectable via non\u2010invasive imaging modalities in rats experiencing early\u2010life adversity. These high\u2010resolution imaging approaches may constitute promising tools for prediction and assessment of at\u2010risk individuals in the clinic. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22661","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T19:16:56Z","timestamp":1474571816000},"page":"1618-1632","source":"Crossref","is-referenced-by-count":119,"title":["MRI uncovers disrupted hippocampal microstructure that underlies memory impairments after early\u2010life adversity"],"prefix":"10.1002","volume":"26","author":[{"given":"Jenny","family":"Molet","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela M.","family":"Maras","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UC\u2010Irvine Irvine CA, 92697\u20104475 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