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Here we show that \u03b2\u2010agonists of norepinephrine facilitate the induction of both associational LTP and sharp wave ripples (SPW\u2010Rs) in acute slices of rat hippocampus in area CA3. Surprisingly, this facilitating effect persists when slices are only pretreated with \u03b2\u2010receptor agonists followed by wash out and application of the unspecific \u03b2\u2010adrenoreceptor (\u03b2AR) antagonist propranolol. During application of \u03b2AR agonists repeated stimulation resulted in facilitated induction of SPW\u2010Rs. Since SPW\u2010Rs are thought to be involved in memory replay we studied the effects of \u03b2AR\u2010agonists on spontaneous SPW\u2010Rs in murine hippocampus and found that amplitude and incidence of SPW\u2010Rs increased. These effects involve cyclic\u2010AMP and the activation of protein kinase A and suggest a supportive role in memory consolidation. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22665","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T15:28:38Z","timestamp":1476199718000},"page":"1486-1492","source":"Crossref","is-referenced-by-count":22,"title":["Pretreatment with \u03b2\u2010adrenergic receptor agonists facilitates induction of LTP and sharp wave ripple complexes in rodent hippocampus"],"prefix":"10.1002","volume":"26","author":[{"given":"Rizwan","family":"ul Haq","sequence":"first","affiliation":[{"name":"Neuroscience Research Center, Charite Universitatsmedizin Berlin  Germany"},{"name":"Department of Pharmacy Abbottabad University of Science &amp; Technology Abbottabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Anderson","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Charite Universitatsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin","family":"Liotta","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Charite Universitatsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Shafiq","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Abbottabad University of Science &amp; Technology Abbottabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Azhar","family":"Sherkheli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Abbottabad University of Science &amp; Technology Abbottabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Heinemann","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Charite Universitatsmedizin Berlin  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1571"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05462.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014507"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90423-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3824-08.2008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04587"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/385533a0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/327620a0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv330"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6091272"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1152\/jn.1988.59.2.667","article-title":"Noradrenergic enhancement of long\u2010term potentiation at mossy fiber synapses in the hippocampus","volume":"59","author":"Hopkins WF","year":"1988","journal-title":"J Neurophysiol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80080-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12941"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00186.2010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.017624"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.044602"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006925"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91106-X"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00249605"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-08-02169.1985"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.09.026"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20918"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4074"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8036517"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.149203"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.22665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.22665","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hipo.22665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T22:55:47Z","timestamp":1696373747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.22665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,18]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/hipo.22665"],"URL":"https:\/\/doi.org\/10.1002\/hipo.22665","archive":["Portico"],"relation":{},"ISSN":["1050-9631","1098-1063"],"issn-type":[{"value":"1050-9631","type":"print"},{"value":"1098-1063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,18]]}}}