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The system \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/hipo22667-math-0002.png\" xlink:title=\"urn:x-wiley:10509631:media:hipo22667:hipo22667-math-0002\" \/> antiporter promotes Na<jats:sup>+<\/jats:sup>\u2010independent exchange of cystine with glutamate thereby providing a major source of extracellular glutamate and intracellular glutathione concentrations. Here we probed the ability of two drugs with opposite effects on system \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/hipo22667-math-0003.png\" xlink:title=\"urn:x-wiley:10509631:media:hipo22667:hipo22667-math-0003\" \/>, the inhibitor sulfasalazine and facilitator N\u2010acetylcysteine, to modulate the ability of A\u00df1\u201042 to inhibit long\u2010term potentiation (LTP) in the CA1 area of the anaesthetized rat. Whereas acute systemic treatment with sulfasalazine lowered the threshold for A\u00df to interfere with synaptic plasticity, N\u2010acetylcysteine prevented the inhibition of LTP by A\u00df alone or in combination with sulfasalazine. Moreover acute N\u2010acetylcysteine also prevented the inhibition of LTP by TNF\u03b1, a putative mediator of A\u00df actions, and repeated systemic N\u2010acetylcysteine treatment for 7 days reversed the delayed deleterious effect of A\u00df on LTP. Since both of these drugs are widely used clinically, further evaluation of their potential beneficial and deleterious actions in early Alzheimer's disease seems warranted. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22667","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T13:09:16Z","timestamp":1476277756000},"page":"1655-1665","source":"Crossref","is-referenced-by-count":7,"title":["Opposite <i>in vivo<\/i> effects of agents that stimulate or inhibit the glutamate\/cysteine exchanger system  on the inhibition of hippocampal LTP by A\u00df"],"prefix":"10.1002","volume":"26","author":[{"given":"Dainan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, and Trinity College Institute of Neuroscience Trinity College Dublin 2 Ireland"},{"name":"Department of Neurosurgery the First Affiliated Hospital of Xinxiang Medical University Weihui 453100 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