{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:06:15Z","timestamp":1792782375272,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"The Velux Foundation; Aase and Ejnar Danielsens Foundation; Director Jacob Madsen and wife Olga Madsens Foundation and Doctor Sofus Carl Emil Friis and wife Doris Friis\u2019 Trust","id":[{"id":"https:\/\/ror.org\/02hcraz70","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1002\/hipo.22670","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T19:26:59Z","timestamp":1476818819000},"page":"52-60","source":"Crossref","is-referenced-by-count":53,"title":["Electroconvulsive stimulation results in long-term survival of newly generated hippocampal neurons in rats"],"prefix":"10.1002","volume":"27","author":[{"given":"Mikkel Vestergaard","family":"Olesen","sequence":"first","affiliation":[{"name":"Department of Neurology, Research Laboratory for Stereology and Neuroscience; Bispebjerg-Frederiksberg Hospital; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitta","family":"W\u00f6rtwein","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology; University of Copenhagen and Mental Health Center Copenhagen; Copenhagen Denmark"},{"name":"Section of Environmental Health, Department of Public Health; University of Copenhagen; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Folke","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Laboratory for Stereology and Neuroscience; Bispebjerg-Frederiksberg Hospital; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Pakkenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Laboratory for Stereology and Neuroscience; Bispebjerg-Frederiksberg Hospital; Copenhagen Denmark"},{"name":"Department of Health and Medical Sciences, Institute of Clinical Medicine; University of Copenhagen; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,31]]},"reference":[{"key":"10.1002\/hipo.22670-BIB0001|hipo22670-cit-0001","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/YCT.0000000000000138","article-title":"Neurotransmitters and electroconvulsive therapy","volume":"30","author":"Baldinger","year":"2014","journal-title":"J ECT"},{"key":"10.1002\/hipo.22670-BIB0002|hipo22670-cit-0002","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.neuron.2012.03.030","article-title":"The age of olfactory bulb neurons in humans","volume":"74","author":"Bergmann","year":"2012","journal-title":"Neuron"},{"key":"10.1002\/hipo.22670-BIB0003|hipo22670-cit-0003","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nan.12107","article-title":"Adult neurogenesis and its role in neuropsychiatric disease, brain repair and normal brain function","volume":"40","author":"Braun","year":"2014","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1002\/hipo.22670-BIB0004|hipo22670-cit-0004","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/cne.1040","article-title":"Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus","volume":"435","author":"Cameron","year":"2001","journal-title":"J Comp Neurol"},{"key":"10.1002\/hipo.22670-BIB0005|hipo22670-cit-0005","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.euroneuro.2008.12.007","article-title":"Repeated electroconvulsive seizures increase the total number of synapses in adult male rat hippocampus","volume":"19","author":"Chen","year":"2009","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1002\/hipo.22670-BIB0006|hipo22670-cit-0006","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/hipo.20718","article-title":"Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression","volume":"20","author":"Chen","year":"2010","journal-title":"Hippocampus"},{"key":"10.1002\/hipo.22670-BIB0007|hipo22670-cit-0007","doi-asserted-by":"crossref","first-page":"12796","DOI":"10.1073\/pnas.211427898","article-title":"Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine","volume":"98","author":"Cz\u00e9h","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hipo.22670-BIB0008|hipo22670-cit-0008","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1046\/j.1365-2818.2001.00958.x","article-title":"Tissue shrinkage and unbiased stereological estimation of particle number and size","volume":"204","author":"Dorph-Petersen","year":"2001","journal-title":"J Microsc"},{"key":"10.1002\/hipo.22670-BIB0009|hipo22670-cit-0009","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/3305","article-title":"Neurogenesis in the adult human hippocampus","volume":"4","author":"Eriksson","year":"1998","journal-title":"Nat Med"},{"key":"10.1002\/hipo.22670-BIB0010|hipo22670-cit-0010","doi-asserted-by":"crossref","first-page":"e1002045","DOI":"10.1371\/journal.pbio.1002045","article-title":"Adult neurogenesis in humans-Common and unique traits in mammals","volume":"13","author":"Ernst","year":"2015","journal-title":"Plos Biol"},{"key":"10.1002\/hipo.22670-BIB0011|hipo22670-cit-0011","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.cell.2014.01.044","article-title":"Neurogenesis in the striatum of the adult human brain","volume":"156","author":"Ernst","year":"2014","journal-title":"Cell"},{"key":"10.1002\/hipo.22670-BIB0012|hipo22670-cit-0012","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1126\/science.287.5457.1433","article-title":"Mammalian neural stem cells","volume":"287","author":"Gage","year":"2000","journal-title":"Science"},{"key":"10.1002\/hipo.22670-BIB0013|hipo22670-cit-0013","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/6365","article-title":"Learning enhances adult neurogenesis in the hippocampal formation","volume":"2","author":"Gould","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1002\/hipo.22670-BIB0014|hipo22670-cit-0014","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2818.1987.tb02837.x","article-title":"The eficiency of systematic sampling in stereology and its prediction","volume":"147","author":"Gundersen","year":"1987","journal-title":"J Microsc"},{"key":"10.1002\/hipo.22670-BIB0015|hipo22670-cit-0015","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1699-0463.1988.tb00954.x","article-title":"The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis","volume":"96","author":"Gundersen","year":"1988","journal-title":"APMIS"},{"key":"10.1002\/hipo.22670-BIB0016|hipo22670-cit-0016","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbr.2008.07.037","article-title":"Electroconvulsive stimulations normalizes stress-induced changes in the glucocorticoid receptor and behaviour","volume":"196","author":"Hageman","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1002\/hipo.22670-BIB0017|hipo22670-cit-0017","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/syn.20796","article-title":"Effects of repeated electroconvulsive seizure on cell proliferation in the rat hippocampus","volume":"64","author":"Ito","year":"2010","journal-title":"Synapse"},{"key":"10.1002\/hipo.22670-BIB0018|hipo22670-cit-0018","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1460-9568.2009.07061.x","article-title":"Quantitative analysis of postnatal neurogenesis and neuron number in the macaque monkey dentate gyrus","volume":"31","author":"Jab\u00e9s","year":"2010","journal-title":"Eur J Neurosci"},{"key":"10.1002\/hipo.22670-BIB0019|hipo22670-cit-0019","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1073\/pnas.2634794100","article-title":"Increased hippocampal neurogenesis in Alzheimer's disease","volume":"101","author":"Jin","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hipo.22670-BIB0020|hipo22670-cit-0020","doi-asserted-by":"crossref","first-page":"13198","DOI":"10.1073\/pnas.0603512103","article-title":"Evidence for stroke-induced neurogenesis in the human brain","volume":"103","author":"Jin","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hipo.22670-BIB0021|hipo22670-cit-0021","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/syn.21553","article-title":"Quantitative hippocampal structural changes following electroconvulsive seizure treatment in a rat model of depression","volume":"66","author":"Kaae","year":"2012","journal-title":"Synapse"},{"key":"10.1002\/hipo.22670-BIB0022|hipo22670-cit-0022","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jad.2009.08.011","article-title":"Rethinking depression and the actions of antidepressants: Uncovering the link between the neural and behavioral elements","volume":"120","author":"Katz","year":"2010","journal-title":"J Affect Disord"},{"key":"10.1002\/hipo.22670-BIB0023|hipo22670-cit-0023","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.cell.2014.02.027","article-title":"Off the beaten track: New neurons in the adult human striatum","volume":"156","author":"Kempermann","year":"2014","journal-title":"Cell"},{"key":"10.1002\/hipo.22670-BIB0024|hipo22670-cit-0024","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/386493a0","article-title":"More hippocampal neurons in adult mice living in an enriched environment","volume":"386","author":"Kempermann","year":"1997","journal-title":"Nature"},{"key":"10.1002\/hipo.22670-BIB0025|hipo22670-cit-0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1242\/dev.00203","article-title":"Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice","volume":"130","author":"Kempermann","year":"2003","journal-title":"Development"},{"key":"10.1002\/hipo.22670-BIB0026|hipo22670-cit-0026","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1192\/bjp.bp.114.158261","article-title":"Evaluation of cumulative cognitive deficits from electroconvulsive therapy","volume":"208","author":"Kirov","year":"2015","journal-title":"Br J Psychiatry"},{"key":"10.1002\/hipo.22670-BIB0027|hipo22670-cit-0027","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1073\/pnas.96.10.5768","article-title":"Continuation of neurogenesis in the hippocampus of the adult macaque monkey","volume":"96","author":"Kornack","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hipo.22670-BIB0028|hipo22670-cit-0028","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1371\/journal.pbio.0040409","article-title":"Functional convergence of neurons generated in the developing and adult hippocampus","volume":"4","author":"Laplagne","year":"2006","journal-title":"PLoS Biol"},{"key":"10.1002\/hipo.22670-BIB0029|hipo22670-cit-0029","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1111\/j.1460-9568.2007.05549.x","article-title":"Similar GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis","volume":"25","author":"Laplagne","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1002\/hipo.22670-BIB0030|hipo22670-cit-0030","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.brainres.2005.09.039","article-title":"Regulation of activity-regulated cytoskeleton protein (Arc) mRNA after acute and chronic electroconvulsive stimulation in the rat","volume":"1064","author":"Larsen","year":"2005","journal-title":"Brain Res"},{"key":"10.1002\/hipo.22670-BIB0031|hipo22670-cit-0031","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/j.1460-9568.2006.04715.x","article-title":"Neurogenesis in the R6\/1 transgenic mouse model of Huntington's disease: Effects of environmental enrichment","volume":"23","author":"Lazic","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1002\/hipo.22670-BIB0032|hipo22670-cit-0032","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00221-003-1658-3","article-title":"Selective loss of hilar neurons and impairment of initial learning in rats after repeated administration of electroconvulsive shock seizures","volume":"154","author":"Lukoyanov","year":"2004","journal-title":"Exp Brain Res"},{"key":"10.1002\/hipo.22670-BIB0033|hipo22670-cit-0033","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0006-3223(00)00228-6","article-title":"Increased neurogenesis in a model of electroconvulsive therapy","volume":"47","author":"Madsen","year":"2000","journal-title":"Biol Psychiat"},{"key":"10.1002\/hipo.22670-BIB0034|hipo22670-cit-0034","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/sj.npp.1300234","article-title":"Cell proliferation in adult hippocampus is decreased by inescapable stress: Reversal by fluoxetine treatment","volume":"28","author":"Malberg","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/hipo.22670-BIB0035|hipo22670-cit-0035","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus","volume":"20","author":"Malberg","year":"2000","journal-title":"J Neurosci"},{"key":"10.1002\/hipo.22670-BIB0036|hipo22670-cit-0036","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: Significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"10.1002\/hipo.22670-BIB0037|hipo22670-cit-0037","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.neuroscience.2004.03.038","article-title":"Chronic restraint stress and chronic corticosterone treatment modulate differentially the expression of molecules related to structural plasticity in the adult rat piriform cortex","volume":"126","author":"Nacher","year":"2004","journal-title":"Neuroscience"},{"key":"10.1002\/hipo.22670-BIB0038|hipo22670-cit-0038","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/hipo.22351","article-title":"Electroconvulsive stimulation, but not chronic restraint stress, causes structural alterations in adult rat hippocampus-A stereological study","volume":"25","author":"Olesen","year":"2015","journal-title":"Hippocampus"},{"key":"10.1002\/hipo.22670-BIB0039|hipo22670-cit-0039","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"key":"10.1002\/hipo.22670-BIB0040|hipo22670-cit-0040","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1523\/JNEUROSCI.0237-07.2007","article-title":"Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates","volume":"27","author":"Perera","year":"2007","journal-title":"J Neurosci"},{"key":"10.1002\/hipo.22670-BIB0041|hipo22670-cit-0041","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1046\/j.1460-9568.2003.02513.x","article-title":"Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus","volume":"17","author":"Pham","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1002\/hipo.22670-BIB0042|hipo22670-cit-0042","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3758\/BF03206553","article-title":"SPSS and SAS procedures for estimating indirect effects in simple mediation models","volume":"36","author":"Preacher","year":"2004","journal-title":"Behav Res Methods Instrum Comput"},{"key":"10.1002\/hipo.22670-BIB0043|hipo22670-cit-0043","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3758\/BRM.40.3.879","article-title":"Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models","volume":"40","author":"Preacher","year":"2008","journal-title":"Behav Res Methods"},{"key":"10.1002\/hipo.22670-BIB0044|hipo22670-cit-0044","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nn1969","article-title":"Adult hippocampal neurogenesis in depression","volume":"10","author":"Sahay","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1002\/hipo.22670-BIB0045|hipo22670-cit-0045","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1002\/hipo.22670-BIB0046|hipo22670-cit-0046","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.cell.2013.05.002","article-title":"Dynamics of hippocampal neurogenesis in adult humans","volume":"153","author":"Spalding","year":"2013","journal-title":"Cell"},{"key":"10.1002\/hipo.22670-BIB0047|hipo22670-cit-0047","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1016\/S0014-2999(99)00800-6","article-title":"Neuropeptide-Y exerts antidepressant-like effects in the forced swim test in rats","volume":"387","author":"Stogner","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1002\/hipo.22670-BIB0048|hipo22670-cit-0048","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/6368","article-title":"Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus","volume":"2","author":"Praag","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1002\/hipo.22670-BIB0049|hipo22670-cit-0049","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/4151030a","article-title":"Functional neurogenesis in the adult hippocampus","volume":"415","author":"Praag","year":"2002","journal-title":"Nature"},{"key":"10.1002\/hipo.22670-BIB0050|hipo22670-cit-0050","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/ar.1092310411","article-title":"Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator","volume":"231","author":"West","year":"1991","journal-title":"Anat Rec"},{"key":"10.1002\/hipo.22670-BIB0051|hipo22670-cit-0051","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1523\/JNEUROSCI.3648-05.2006","article-title":"Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus","volume":"26","author":"Zhao","year":"2006","journal-title":"J Neurosci"},{"key":"10.1002\/hipo.22670-BIB0052|hipo22670-cit-0052","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"}],"container-title":["Hippocampus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.22670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhipo.22670","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/hipo.22670\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T18:27:57Z","timestamp":1625250477000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.22670"}},"subtitle":["SURVIVAL OF NEWLY FORMED NEURONS IN THE RAT HIPPOCAMPUS"],"short-title":[],"issued":{"date-parts":[[2016,10,31]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"URL":"https:\/\/doi.org\/10.1002\/hipo.22670","archive":["Portico"],"relation":{},"ISSN":["1050-9631"],"issn-type":[{"value":"1050-9631","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10,31]]}}}