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The present study was designed to examine whether the perceptual alterations induced by a serotonergic psychedelic drug would affect the integrity of hippocampal\u2010dependent, visually guided spatial cognition. phenylalkylamine hallucinogen TCB\u20102 is a selective agonist of 5\u2010HT<jats:sub>2A<\/jats:sub>Rs. Mice received TCB\u20102 (1.0 mg\u00a0kg<jats:sup>\u22121<\/jats:sup>, i.p.), and spatial behaviors and hippocampal electrophysiological responses were measured with water maze tasks and <jats:italic>in vivo<\/jats:italic> single\u2010unit recording, respectively. TCB\u20102 did not affect visual cue approach behavior in the visible platform water maze, but increased the latency of trained mice to initiate goal\u2010directed swimming during a probe test in the hidden platform Morris water maze, which could be prevented by 5\u2010HT<jats:sub>2A<\/jats:sub>R antagonist MDL 11,939. Interestingly, TCB\u20102 did not affect the efficiency of the swim path or the proper use of distal visual cues during the probe test. Hippocampal place cell activity is considered to represent spatial and context\u2010specific episodic memory. Systemic TCB\u20102 did not affect previously established place fields of CA1 neurons in mice exploring a familiar environment, or the remapping of place cells when the mice explored a novel environment. However, TCB\u20102 impaired the long\u2010term stability of place fields for the novel environment initially encoded under the influence of TCB\u20102, which could be prevented by 5\u2010HT<jats:sub>2A<\/jats:sub>R antagonist MDL 11,939. Our data indicate that hallucinogenic 5\u2010HT<jats:sub>2A<\/jats:sub>R agonist delays the initiation of spatial search behavior, but does not impair the use of visual cues to guide goal\u2010directed spatial behavior. Moreover, activation of 5\u2010HT<jats:sub>2A<\/jats:sub>Rs does not impair the coding and retrieval of spatial information, but impairs the long\u2010term stability of new formed place fields of CA1 neurons. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22712","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T08:35:52Z","timestamp":1486542952000},"page":"558-569","source":"Crossref","is-referenced-by-count":18,"title":["Effect of a hallucinogenic serotonin 5\u2010HT<sub>2A<\/sub> receptor agonist on visually guided, hippocampal\u2010dependent spatial cognition in C57BL\/6J mice"],"prefix":"10.1002","volume":"27","author":[{"given":"Gongliang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences, Anhui Medical University Hefei Anhui China"},{"name":"Jupiter Life Science Initiative Florida Atlantic University Jupiter Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cinalli","sequence":"additional","affiliation":[{"name":"Department of Psychology Charles E. Schmidt College of Science, Florida Atlantic University Jupiter Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Robert W.","family":"Stackman","sequence":"additional","affiliation":[{"name":"Jupiter Life Science Initiative Florida Atlantic University Jupiter Florida"},{"name":"Department of Psychology Charles E. 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