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The involvement of the hippocampus during acquisition is well described; however we know much less about the concomitant contribution of cortical activity levels to the formation of stable remote memories. Here, after a reversible pharmacological inhibition of the anterior cingulate cortex (ACC) during the acquisition of a contextual fear conditioning, retrieval of both recent and remote memories were impaired, an effect that was reverted by a single memory reactivation session 48 h after training, through a destabilization\u2010dependent mechanism interpreted as reconsolidation, that restored the normal course of systems consolidation in order to rescue a remote memory. Next we have shown that the integrity of both the anterior cingulate cortex and the thalamic nucleus reuniens (RE) were required for this reactivation\u2010induced memory rescue. Because lidocaine infused into the RE inhibited LTP induction in the CA1\u2010anterior cingulate cortex pathways, it seems that RE is a necessary component of the circuit underlying systems consolidation, mediating communication between dorsal hippocampus and cortical areas. To our notice, this is the first demonstration of the rescue of remote memories disrupted by ACC inhibition during acquisition, via a reconsolidation\u2010driven mechanism. We have also shown the importance of RE to ensure the interconnection among brain areas that collectively seem to control the natural course of systems consolidation and allow the persistence of relevant emotional engrams. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hipo.22715","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T08:38:53Z","timestamp":1486543133000},"page":"596-607","source":"Crossref","is-referenced-by-count":50,"title":["Reconsolidation\u2010induced rescue of a remote fear memory blocked by an early cortical inhibition: Involvement of the anterior cingulate cortex and the mediation by the thalamic nucleus reuniens"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4587-0566","authenticated-orcid":false,"given":"Rodrigo O.","family":"Sierra","sequence":"first","affiliation":[{"name":"Psychobiology and Neurocomputing Lab Biophysics Department, IB, CEP 91.501\u2010970, Universidade 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Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Santana","sequence":"additional","affiliation":[{"name":"Psychobiology and Neurocomputing Lab Biophysics Department, IB, CEP 91.501\u2010970, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Graduate Program in Neuroscience ICBS, CEP 90.046\u2010900, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Z.","family":"Boos","sequence":"additional","affiliation":[{"name":"Psychobiology and Neurocomputing Lab Biophysics Department, IB, CEP 91.501\u2010970, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Graduate Program in Neuroscience ICBS, CEP 90.046\u2010900, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana 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