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Performance on mnemonic similarity tasks, which test high\u2010level discrimination, declines with advancing age in humans and these deficits have been linked to altered activity in hippocampal CA3 and dentate gyrus. Lesion studies in animal models, however, point to the perirhinal cortex as a brain region critical for sensory discriminations that serve memory. Reconciliation of the contributions of different regions within the cortical\u2013hippocampal circuit requires the development of a discrimination paradigm comparable to the human mnemonic similarity task that can be used in rodents. In the present experiments, young and aged rats were cross\u2010characterized on a spatial water maze task and two variants of an object discrimination task: one in which rats incrementally learned which object of a pair was rewarded and different pairs varied in their similarity (Experiment 1), and a second in which rats were tested on their ability to discriminate a learned target object from multiple lure objects with an increasing degree of feature overlap (Experiment 2). In Experiment 1, aged rats required more training than young to correctly discriminate between similar objects. Comparably, in Experiment 2, aged rats were impaired in discriminating a target object from lures when the pair shared more features. Discrimination deficits across experiments were correlated within individual aged rats, though, for the cohort tested, aged rats were not impaired overall in spatial learning and memory. This could suggest discrimination deficits emerging with age precede declines in spatial or episodic memory, an observation that has been made in humans. Findings of robust impairments in object discrimination abilities in the aged rats parallel results from human studies, supporting use of the developed tasks for mechanistic investigation of cortical\u2013hippocampal circuit dysfunction in aging and disease.<\/jats:p>","DOI":"10.1002\/hipo.22729","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T10:40:48Z","timestamp":1490438448000},"page":"759-776","source":"Crossref","is-referenced-by-count":57,"title":["Rodent age\u2010related impairments in discriminating perceptually similar objects parallel those observed in humans"],"prefix":"10.1002","volume":"27","author":[{"given":"Sarah A.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Evelyn F. &amp; William L. 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