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Here, we examined hippocampal subfield volumes in 29 pediatric brain tumor survivors treated with cranial radiation and chemotherapy, and 30 healthy developing children and adolescents. We also examined associations between hippocampal subfield volumes and short\u2010term verbal memory. Hippocampal subfields (Cornus Ammonis (CA) 1, CA2\u20103, dentate gyrus (DG)\u2010CA4, stratum radiatum\u2014lacunosum\u2014moleculare, and subiculum) were segmented using the Multiple Automatically Generated Templates for Different Brains automated segmentation algorithm. Neuropsychological assessment of short\u2010term verbal associative memory was performed in a subset of brain tumor survivors (<jats:italic>N<\/jats:italic>\u2009=\u200911) and typically developing children (<jats:italic>N<\/jats:italic>\u2009=\u200916), using the Children's Memory Scale or Wechsler's Memory Scale\u2014third edition. Repeated measures analysis of variance showed that pediatric brain tumor survivors had significantly smaller DG\u2010CA4, CA1, CA2\u20103, and stratum radiatum\u2010lacunosum\u2010moleculare volumes compared with typically developing children. Verbal memory performance was positively related to DG\u2010CA4, CA1, and stratum radiatum\u2010lacunosum\u2010moleculare volumes in pediatric brain tumor survivors. Unlike the brain tumor survivors, there were no associations between subfield volumes and memory in typically developing children and adolescents. These data suggest that specific subfields of the hippocampus may be vulnerable to brain cancer treatments, and may contribute to impaired episodic memory following brain cancer treatment in childhood.<\/jats:p>","DOI":"10.1002\/hipo.22758","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T07:52:38Z","timestamp":1498895558000},"page":"1140-1154","source":"Crossref","is-referenced-by-count":35,"title":["Smaller hippocampal subfield volumes predict verbal associative memory in pediatric brain tumor survivors"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-2073","authenticated-orcid":false,"given":"Alexandra L.","family":"Decker","sequence":"first","affiliation":[{"name":"Neurosciences and Mental Health Hospital for Sick Children Toronto Canada"},{"name":"Department of Psychology University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila U.","family":"Szulc","sequence":"additional","affiliation":[{"name":"Neurosciences and Mental Health Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bouffet","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Laughlin","sequence":"additional","affiliation":[{"name":"Diagnositic Imaging The Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Mallar","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"Cerebral Imaging Centre, Douglas Mental Health University Institute Montreal Canada"},{"name":"Departments of Psychiatry and Biological and Biomedical Engineering McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovanka","family":"Skocic","sequence":"additional","affiliation":[{"name":"Neurosciences and Mental Health Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia B.","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Neurosciences and Mental Health Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Mabbott","sequence":"additional","affiliation":[{"name":"Neurosciences and Mental Health Hospital for Sick Children Toronto Canada"},{"name":"Department of Psychology University of Toronto Toronto Canada"},{"name":"Department of Psychology Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869609083995"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90424-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)63001-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(91)90031-K"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051258"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn227"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/15.4.585"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950060041004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00476-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702116104"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040844"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22092"},{"key":"e_1_2_7_14_1","article-title":"Altered resting\u2010state hippocampal functional networks associated with chemotherapy\u2010induced prospective memory impairment in breast cancer survivors","volume":"7","author":"Cheng H.","year":"2017","journal-title":"Scientific Reports"},{"issue":"7","key":"e_1_2_7_15_1","first-page":"1954","article-title":"Impaired Cognitive Function and Hippocampal Neurogenesis following Cancer Chemotherapy","volume":"18","author":"Christie L.\u2010A.","year":"2012","journal-title":"American Association for Cancer Research"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173215"},{"key":"e_1_2_7_17_1","unstructured":"Cohen. 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