{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:26:19Z","timestamp":1761060379529,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a substantial body of evidence that the hippocampus (HPC) plays and essential role in context discrimination in rodents. Studies reporting anterograde amnesia (AA) used repeated, alternating, distributed conditioning and extinction sessions to measure context fear discrimination. In addition, there is uncertainty about the extent of damage to the HPC. Here, we induced conditioned fear prior to discrimination tests and rats sustained extensive, quantified pre\u2010 or post\u2010training HPC damage. Unlike previous work, we found that extensive HPC damage spares context discrimination, we observed no AA. There must be a non\u2010HPC system that can acquire long\u2010term memories that support context fear discrimination. Post\u2010training HPC damage caused retrograde amnesia (RA) for context discrimination, even when rats are fear conditioned for multiple sessions. We discuss the implications of these findings for understanding the role of HPC in long\u2010term memory.<\/jats:p>","DOI":"10.1002\/hipo.22759","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T18:26:37Z","timestamp":1499451997000},"page":"951-958","source":"Crossref","is-referenced-by-count":18,"title":["Hippocampal damage causes retrograde but not anterograde memory loss for context fear discrimination in rats"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7637-0014","authenticated-orcid":false,"given":"Justin Q.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neuroscience Canadian Centre for Behavioural Neuroscience, University of Lethbridge  Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Canadian Centre for Behavioural Neuroscience, University of Lethbridge  Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Canadian Centre for Behavioural Neuroscience, University of Lethbridge  Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,17]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.2001.4008"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.99.2.195"},{"volume-title":"The hippocampus as a cognitive map","year":"1978","author":"O'Keefe J.","key":"e_1_2_4_4_1"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2618-15.2015"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03337828"},{"key":"e_1_2_4_7_1","first-page":"326","volume-title":"Memory, Amnesia, and the Hippocampal System","author":"Cohen N. 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