{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:09:45Z","timestamp":1789085385499,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG Pl 248\/4\u20101"],"award-info":[{"award-number":["DFG Pl 248\/4\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adaptive behavior frequently depends on inference from past experience. Recent studies suggest that the underlying process of integrating related memories may depend on interaction between hippocampus and prefrontal cortex. Here, we investigated how hippocampal damage affects memory integration. Subjects with mediotemporal lesions and healthy controls learned a set of overlapping AB\u2010 and BC\u2010associations (object\u2010face\u2010 and face\u2010object pairs) and were then tested for memory of these associations (\u201cdirect\u201d trials) and of inferential AC\u2010associations (\u201cindirect\u201d trials). The experiment consisted of four encoding\/retrieval cycles. In direct trials, performance of patients and controls was similar and stable across cycles. By contrast, in indirect trials, patients and controls showed distinct patterns of behavior. Whereas patients and controls initially showed only minor differences, controls increased performance across subsequent cycles, while patient performance decreased to chance level. Further analysis suggested that this deficit was not merely a consequence of impaired associative memory but rather resulted from an additional hippocampal contribution to memory integration. Our findings further suggest that contextual factors modulate this contribution. Patient deficits in more complex memory\u2010guided behavior may depend on the flexible interaction of hippocampus\u2010dependent and \u2010independent mechanisms of memory integration.<\/jats:p>","DOI":"10.1002\/hipo.22766","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T16:06:47Z","timestamp":1501690007000},"page":"1230-1238","source":"Crossref","is-referenced-by-count":25,"title":["Memory integration in humans with hippocampal lesions"],"prefix":"10.1002","volume":"27","author":[{"given":"Anna","family":"Pajkert","sequence":"first","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin D\u201010117 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Finke","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin D\u201010117 Germany"},{"name":"Berlin School of Mind &amp; Brain Humboldt\u2010Universit\u00e4t zu Berlin Berlin D\u201010117 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Lee","family":"Shing","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Development Center for Lifespan Psychology Berlin D\u201014195 Germany"},{"name":"Division of Psychology, Faculty of Natural Sciences University of Stirling  Scotland FK94LA United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin D\u201010117 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology and Psychophysiology, Institute of Psychology Humboldt\u2010Universit\u00e4t zu Berlin Berlin D\u201010099 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke R.","family":"Heekeren","sequence":"additional","affiliation":[{"name":"Department of Education and Psychology Freie Universit\u00e4t Berlin Berlin D\u201014195 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-4530","authenticated-orcid":false,"given":"Christoph J.","family":"Ploner","sequence":"additional","affiliation":[{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin D\u201010117 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7441.702"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a3167"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0028667"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3515"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/379255a0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.12110268"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.13.7109"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu270"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2015.12.024"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0185-14.2014"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.148"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.04.023"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13346"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10189"},{"key":"e_1_2_5_16_1","volume-title":"Leistungspr\u00fcfsystem","author":"Horn W.","year":"1983"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.03.012"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.04.008"},{"key":"e_1_2_5_19_1","volume-title":"Mehrfachwahl\u2010Wortschatz\u2010Intelligenztest","author":"Lehrl S.","year":"2005"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.06.017"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2010.07.013"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/xge0000158"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.22.5.681"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892903321208123"},{"key":"e_1_2_5_25_1","first-page":"345","article-title":"The medial temporal lobes are critical for reward\u2010based decision making under conditions that promote episodic future thinking","volume":"353","author":"Palombo D. 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