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Further, no effective treatment exists to combat intellectual disability and basal forebrain cholinergic neurodegeneration seen in DS. To further our understanding of gene expression changes before and following cholinergic degeneration in a well\u2010established mouse model of DS\/AD, the Ts65Dn mouse, we assessed RNA expression levels from CA1 pyramidal neurons at two adult ages (\u223c6 months of age and \u223c11 months of age) in both Ts65Dn and their normal disomic (2N) littermates. We further examined a therapeutic intervention, maternal choline supplementation (MCS), which has been previously shown to lessen dysfunction in spatial cognition and attention, and have protective effects on the survival of basal forebrain cholinergic neurons in the Ts65Dn mouse model. Results indicate that MCS normalized expression of several genes in key gene ontology categories, including synaptic plasticity, calcium signaling, and AD\u2010associated neurodegeneration related to amyloid\u2010beta peptide (A\u03b2) clearance. Specifically, normalized expression levels were found for endothelin converting enzyme\u20102 (<jats:italic>Ece2<\/jats:italic>), insulin degrading enzyme (<jats:italic>Ide<\/jats:italic>), <jats:italic>Dyrk1a<\/jats:italic>, and calcium\/calmodulin\u2010dependent protein kinase II (<jats:italic>Camk2a<\/jats:italic>), among other relevant genes. Single population expression profiling of vulnerable CA1 pyramidal neurons indicates that MCS is a viable therapeutic for long\u2010term reprogramming of key transcripts involved in neuronal signaling that are dysregulated in the trisomic mouse brain which have translational potential for DS and AD.<\/jats:p>","DOI":"10.1002\/hipo.22832","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T23:00:03Z","timestamp":1517612403000},"page":"251-268","source":"Crossref","is-referenced-by-count":36,"title":["CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation"],"prefix":"10.1002","volume":"28","author":[{"given":"Melissa J.","family":"Alldred","sequence":"first","affiliation":[{"name":"Center for Dementia Research, Nathan Kline Institute Orangeburg New York"},{"name":"Department of Psychiatry New York University Langone Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Chao","sequence":"additional","affiliation":[{"name":"Center for Dementia Research, Nathan Kline Institute Orangeburg New York"},{"name":"Department of Psychiatry New York University Langone Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute Orangeburg New York"},{"name":"Child and Adolescent Psychiatry New York University Langone Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judah","family":"Beilin","sequence":"additional","affiliation":[{"name":"Center for Dementia Research, Nathan Kline Institute Orangeburg New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Powers","sequence":"additional","affiliation":[{"name":"Department of Psychology Cornell University Ithaca New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Petkova","sequence":"additional","affiliation":[{"name":"Child Psychiatry Nathan Kline Institute Orangeburg New York"},{"name":"Child and Adolescent Psychiatry New York University Langone Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Strupp","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences Cornell University Ithaca New York"},{"name":"Department of Psychology Cornell University Ithaca New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1797-4288","authenticated-orcid":false,"given":"Stephen D.","family":"Ginsberg","sequence":"additional","affiliation":[{"name":"Center for Dementia Research, Nathan Kline Institute Orangeburg New York"},{"name":"Department of Psychiatry New York University Langone Medical Center New York New York"},{"name":"NYU Neuroscience Institute, New York University Langone Medical Center New York New York"},{"name":"Neuroscience &amp; Physiology New York University Langone Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"ABI. 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