{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:57:32Z","timestamp":1790668652156,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T00:00:00Z","timestamp":1519430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["1042584"],"award-info":[{"award-number":["1042584"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"Victorian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hippocampus"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however, there are a range of \u2018non\u2010movement\u2019 related features of PD including cognitive dysfunction, sleep disturbances and mood disorders. The origins for these non\u2010motor symptoms are less clear, but a possible substrate for cognitive decline may be reduced adult\u2010hippocampal neurogenesis, which is reported to be impaired in PD. The mechanisms underlying reduced neurogenesis in PD are not well established. Here we tested the hypothesis that NA and DA depletion, as occurs in PD, impairs hippocampal neurogenesis. We used 6<jats:italic>\u2010<\/jats:italic>hydroxydopamine or the immunotoxin dopamine\u2010\u03b2\u2010hydroxylase\u2010saporin to selectively lesion DA or NA neurons, respectively, in adult Sprague Dawley rats and assessed hippocampal neurogenesis through phenotyping of cells birth\u2010dated using 5\u2010bromo\u20102\u2032\u2010deoxyuridine. The results showed no difference in proliferation or differentiation of newborn cells in the subgranular zone of the dentate gyrus after NA or DA lesions. This suggests that impairment of hippocampal neurogenesis in PD likely results from mechanisms independent of, or in addition to degeneration of DA and NA neurons.<\/jats:p>","DOI":"10.1002\/hipo.22835","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T12:32:42Z","timestamp":1518438762000},"page":"327-337","source":"Crossref","is-referenced-by-count":19,"title":["Modelling the dopamine and noradrenergic cell loss that occurs in Parkinson's disease and the impact on hippocampal neurogenesis"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4726-1120","authenticated-orcid":false,"given":"Charlotte M.","family":"Ermine","sequence":"first","affiliation":[{"name":"Neurodegeneration division, The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan L.","family":"Wright","sequence":"additional","affiliation":[{"name":"Neurodegeneration division, The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Frausin","sequence":"additional","affiliation":[{"name":"Neurodegeneration division, The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Kauhausen","sequence":"additional","affiliation":[{"name":"Neurodegeneration division, The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare L.","family":"Parish","sequence":"additional","affiliation":[{"name":"Neurodegeneration division, The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davor","family":"Stanic","sequence":"additional","affiliation":[{"name":"Neurodegeneration division, The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachlan H.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Neurodegeneration division, The Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.11.036"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03486.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.01.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20130001"},{"issue":"11","key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1093\/brain\/awr256","article-title":"The proliferative capacity of the subventricular zone is maintained in the Parkinsonian brain","volume":"134","author":"den Berge S. 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