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In this study, we sought to determine the role of action potential (AP)\u2010dependent synaptic transmission by adult\u2010generated dentate granule cells (DGCs) in their survival and function within the existing circuitry. We used a triple transgenic mouse (NestinCreER<jats:sup>T2<\/jats:sup>:Snap25<jats:sup>fl\/fl<\/jats:sup>: tdTomato) to inducibly inactivate AP\u2010dependent synaptic transmission within adult hippocampal progenitors and their progeny. Behavioral testing in a hippocampal\u2010dependent A\/B contextual fear\u2010discrimination task revealed impaired discrimination learning in mice harboring SNAP\u201025\u2010deficient adult\u2010generated dentate granule cells (DGCs). Despite poor performance on this neurogenesis\u2010dependent task, the production and survival of newborn DGCs was quantitatively unaltered in tamoxifen\u2010treated NestinCreER<jats:sup>T2<\/jats:sup>:Snap25<jats:sup>fl\/fl<\/jats:sup>: tdTomato SNAP compared to tamoxifen\u2010treated NestinCreER<jats:sup>T2<\/jats:sup>:Snap25<jats:sup>wt\/wt<\/jats:sup>: tdTomato control mice. Although SNAP\u201025\u2010deficient adult DGCs displayed a small but statistically significant enhancement in proximal dendritic branching, their overall dendritic length and distal branching complexity was unchanged. SNAP\u201025\u2010deficient newborn DGCs also displayed robust efferent mossy fiber output to CA3, with normal linear density of large mossy fiber terminals (LMTs). These studies suggest that AP\u2010dependent neurotransmitter release by newborn DGCs is not essential for their survival or rudimentary structural maturation within the adult hippocampus.<\/jats:p>","DOI":"10.1002\/hipo.23008","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T15:15:01Z","timestamp":1531322101000},"page":"735-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genetic inactivation of synaptosomal\u2010associated protein 25 (SNAP\u201025) in adult hippocampal neural progenitors impairs pattern discrimination learning but not survival or structural maturation of newborn dentate granule cells"],"prefix":"10.1002","volume":"28","author":[{"given":"Kymberly C.","family":"Gustus","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Chander","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Weick","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0294-5262","authenticated-orcid":false,"given":"Lee Anna","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico Health Sciences Center  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-09-03386.1998"},{"key":"e_1_2_6_3_1","first-page":"6","article-title":"Adult\u2010born neurons modify excitatory synaptic transmission to existing neurons","author":"Adlaf E. 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