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In the<jats:italic>reeler<\/jats:italic>mutant, the absence of Reelin causes severe defects in the radial migration of neurons, resulting in abnormal cortical layering. To date, the exact morphological properties of CR\u2010cells independent of Reelin are unknown. With this in view, we studied the ontogenesis, density, and distribution of CR\u2010cells in<jats:italic>reeler<\/jats:italic>mice that were cross\u2010bred with a CXCR4\u2010EGFP reporter mouse line, thus enabling us to clearly identify CR\u2010cells positions in the disorganized hippocampus of the<jats:italic>reeler<\/jats:italic>mouse. As evidenced by morphological analysis, differences were found regarding CR\u2010cell distribution and density: generally, we found fewer CR\u2010cells in the developing and adult<jats:italic>reeler<\/jats:italic>hippocampus as compared to the hippocampus of wild\u2010type animals (WT); however, in<jats:italic>reeler<\/jats:italic>mice, CR\u2010cells were much more closely associated to the hippocampal fissure (HF), resulting in relatively higher local CR\u2010cell densities. This higher local cell density was accompanied by stronger immunoreactivity of the CXCR4 ligand, stroma\u2010derived factor\u20101 (SDF\u20101) that is known to regulate CR\u2010cell positioning. Importantly, confocal microscopy indicates an integration of CR\u2010cells into the developing and adult hippocampal network in<jats:italic>reeler<\/jats:italic>mice, raising evidence that network integration of CR\u2010cells might be independent of Reelin.<\/jats:p>","DOI":"10.1002\/hipo.23049","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T11:53:46Z","timestamp":1541418826000},"page":"550-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Integrity of Cajal\u2013Retzius cells in the<i>reeler<\/i>\u2010mouse hippocampus"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3071-5835","authenticated-orcid":false,"given":"Max","family":"Anst\u00f6tz","sequence":"first","affiliation":[{"name":"Institute of Neuroanatomy, University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg 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